Institute for Regenerative Medicine, Shanghai East Hospital, Shanghai Key Lab of D&A for Metal Functional Materials, School of Life Scxience and Technology, School of Materials Science and Engineering, Tongji University, Shanghai 200123, China.
Department of Oral Maxillofacial-Head and Neck Oncology, Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, National Clinical Research Center of Stomatology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
J Mater Chem B. 2020 Sep 30;8(37):8671-8683. doi: 10.1039/d0tb01021a.
Multifunctional nanomedical platforms have broad prospects in imaging-guided combination therapy in cancer precision medicine. In this work, metal-organic framework (MOF)-derived novel porous Fe3O4@C nanocomposites were developed as an intelligent cancer nanomedical platform for combined cancer therapy with MRI-guided magnetic-triggered hyperthermia and chemotherapy functions. The magnetic behavior, porous character and good surface modification endowed this smart nanoplatform with favorable biocompatibility, high-efficiency MRI imaging, magnetic-triggered on-demand DOX release function, and synergistic therapy of magnetic hyperthermia and chemotherapy, which proposed an all-in-one platform for cancer therapy. Additionally, in vivo animal experiments verified the significant suppression of malignant tumor growth with negligible side effects, which were attributed to the consecutive 13 day synergistic therapy of magnetic hyperthermia and chemotherapy in one. To be specific, Fe3O4@C-PVP@DOX significantly decreases the volume (2.5 to 0.44 of tumor volume ratio) and weight (0.49 g to 0.10 g) of tumors after magnetic-triggered hyperthermia and chemotherapy treatments. Moreover, no big difference of body weight and associated damage was observed among all major organs. Therefore, owing to its high-efficiency combined therapy of magnetic-triggered hyperthermia and chemotherapy, this smart nanoplatform holds great potential application in the precise treatments of clinical cancer.
多功能纳米医学平台在癌症精准医学的成像引导联合治疗中具有广阔的前景。在这项工作中，开发了一种基于金属有机框架（MOF）衍生的新型多孔 Fe3O4@C 纳米复合材料，作为一种智能癌症纳米医学平台，用于结合 MRI 引导的磁触发热疗和化学疗法的癌症联合治疗。这种智能纳米平台具有良好的磁性、多孔性和良好的表面修饰，赋予其良好的生物相容性、高效的 MRI 成像、磁触发按需 DOX 释放功能以及磁热疗和化学疗法的协同治疗，为癌症治疗提供了一种一体化的平台。此外，体内动物实验验证了恶性肿瘤生长的显著抑制，且副作用极小，这归因于磁热疗和化学疗法的连续 13 天协同治疗。具体来说，在磁触发热疗和化疗治疗后，Fe3O4@C-PVP@DOX 显著降低了肿瘤的体积（肿瘤体积比从 2.5 降至 0.44）和重量（肿瘤重量从 0.49 g 降至 0.10 g）。此外，在所有主要器官中，体重和相关损伤没有明显差异。因此，由于其高效的磁触发热疗和化学疗法的联合治疗，这种智能纳米平台在癌症的精确治疗中具有很大的应用潜力。
