Estevez M E, Ballart I J, Diez R A, Sen L, Nicastro M A, Wechsler A
Cancer. 1985 Jun 15;55(12):2774-8. doi: 10.1002/1097-0142(19850615)55:12<2774::aid-cncr2820551209>3.0.co;2-6.
In a previous work, the authors found that the peripheral blood monocytes from patients with Hodgkin's disease (HD) had depressed lytic capability to kill Candida pseudotropicalis and depressed phagocytic function. The aim of this study was to evaluate if cyclooxygenase inhibitors could correct the defective macrophage functions. Fifteen untreated patients with HD and 10 normal subjects were studied. The incubation of the cells from the patients with HD with indomethacin (IM) at 1, 3, and 10 micrograms/ml and with acetylsalicylic acid (ASA) at 20 micrograms/ml increased their previously deficient ability to kill C. pseudotropicalis, reaching values close to those of normal subjects. The oral administration of ASA during 1 week also corrected the monocyte lytic deficiency in the patients' group. Neither the in vitro nor the in vivo treatment with these cyclooxygenase inhibitors had any significant effect on normal subjects' monocytes' lytic function. The drugs did not improve the impaired phagocytic function in patients with HD. These results indicate that the failure of the lytic activity of the monocytes in HD could be associated to an excessive production of PGE2, and the oral administration of inhibitors of the cyclooxygenase activity can correct such abnormality whereas the phagocytic dysfunction is not reverted by them.
在先前的一项研究中，作者发现霍奇金病（HD）患者的外周血单核细胞对热带假丝酵母菌的杀伤溶解能力降低，吞噬功能也受到抑制。本研究的目的是评估环氧化酶抑制剂是否能够纠正巨噬细胞的功能缺陷。研究了15例未经治疗的HD患者和10名正常受试者。HD患者的细胞与浓度为1、3和10微克/毫升的吲哚美辛（IM）以及浓度为20微克/毫升的乙酰水杨酸（ASA）共同孵育后，其先前缺乏的杀伤热带假丝酵母菌的能力有所增强，接近正常受试者的水平。在1周内口服ASA也纠正了患者组单核细胞的溶解缺陷。这些环氧化酶抑制剂的体外和体内治疗对正常受试者单核细胞的溶解功能均无显著影响。这些药物并未改善HD患者受损的吞噬功能。这些结果表明，HD患者单核细胞溶解活性的降低可能与PGE2的过度产生有关，口服环氧化酶活性抑制剂可以纠正这种异常，而吞噬功能障碍则不能被它们逆转。
