Huang Yongjiao, He Wei, Zhang Yingting, Zou Zhihui, Han Longchuan, Luo Jing, Wang Yunqiu, Tang Xinxin, Li Yue, Bao Yuhan, Huang Ying, Long Xi-Dai, Fu Yinkun, He Ming
Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of Ministry of Education, Shanghai Frontiers Science Center of Cellular Homeostasis and Human Diseases, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
School of Basic Medicine, DeHong Vocational College, Dehong, Yunnan, China.
Aging Dis. 2024 Aug 15. doi: 10.14336/AD.202.0513.
Aging is a complex biological process that involves multi-level structural and physiological changes. Aging is a major risk factor for many chronic diseases. The accumulation of senescent cells changes the tissue microenvironment and is closely associated with the occurrence and development of tissue and organ fibrosis. Fibrosis is the result of dysregulated tissue repair response in the development of chronic inflammatory diseases. Recent studies have clearly indicated that SIRT2 is involved in regulating the progression of fibrosis, making it a potential target for anti-fibrotic drugs. SIRT2 is a NAD dependent histone deacetylase, shuttling between nucleus and cytoplasm, and is highly expressed in liver, kidney and heart, playing an important role in the occurrence and development of aging and fibrosis. Therefore, we summarized the role of SIRT2 in liver, kidney and cardiac fibrosis during aging.
