Tang Lingxue, Wang Shuo, Hu Jie, Meng Lili, Zhang Jie, Chang Yi, Ma Xiaoming, Guo Yuming
School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, Henan 453007, China.
Key Laboratory of Green Chemical Media and Reactions, Henan Normal University, Xinxiang, Henan 453007, China.
Colloids Surf B Biointerfaces. 2025 Jan;245:114188. doi: 10.1016/j.colsurfb.2024.114188. Epub 2024 Aug 30.
To maximize the therapeutic effects and minimize the adverse effects of synergistic tumor therapies, a multifunctional nanozyme Au-Bi/ZIF-8@DOX@HA (ABZ@DOX@HA) was designed and synthesized through the Au and Bi bimetallic doping of ZIF-8, loading of the DOX, and modifying with hyaluronic acid (HA). The ABZ@DOX@HA nanoparticles (NPs) could simulate the enzymatic activities of glucose oxidase (GOx) and peroxidase (POD). Upon irradiated by near-infrared region (NIR-II) laser, the strong synergism of the photothermal abilities of the loaded Au and Bi nanodots accelerated the collapse of the ABZ structure at the tumor site considerably and released Au, Bi nanodots and DOX. The results in vitro and in vivo proved that ABZ@DOX@HA nanozyme could effectively exert the combined tumor therapy of starvation treatment, photothermal therapy (PTT), chemodynamic therapy (CDT) and chemotherapy. The current research provides a new strategy to address the inherent challenges of easy clearance and short blood circulation of small-sized NPs during the treatment of tumors with nanomedicine, as well as the aggregation and oxidation of inorganic nanodots.
为了最大化协同肿瘤治疗的疗效并最小化其副作用，通过对ZIF-8进行金（Au）和铋（Bi）双金属掺杂、负载阿霉素（DOX）以及用透明质酸（HA）修饰，设计并合成了一种多功能纳米酶Au-Bi/ZIF-8@DOX@HA（ABZ@DOX@HA）。ABZ@DOX@HA纳米颗粒（NPs）能够模拟葡萄糖氧化酶（GOx）和过氧化物酶（POD）的酶活性。在近红外二区（NIR-II）激光照射下，负载的Au和Bi纳米点的光热能力产生的强烈协同作用极大地加速了肿瘤部位ABZ结构的崩塌，并释放出Au、Bi纳米点和DOX。体外和体内实验结果证明，ABZ@DOX@HA纳米酶能够有效地发挥饥饿治疗、光热治疗（PTT）、化学动力治疗（CDT）和化疗的联合肿瘤治疗作用。当前的研究为解决纳米药物治疗肿瘤过程中小尺寸NPs易清除和血液循环时间短以及无机纳米点聚集和氧化等固有挑战提供了一种新策略。
