Department of Microbial Infection and Immunity, College of Medicine, The Ohio State University, Columbus, OH, USA; Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH, USA.
Department of Microbial Infection and Immunity, College of Medicine, The Ohio State University, Columbus, OH, USA.
Cell Immunol. 2024 Sep-Oct;403-404:104865. doi: 10.1016/j.cellimm.2024.104865. Epub 2024 Sep 2.
Bacille-Calmette-Guérin (BCG) is the only approved vaccine against Mycobacterium tuberculosis (MTB), offering protection not only against tuberculosis (TB) but also non-related infections. 'Trained immunity' of innate immune cells is considered one of the mechanisms of this broad protection derived through BCG. Here, we investigated the effect of BCG on Natural Killer (NK) cells, a key innate immune cell type, and their subsequent responses to mycobacterial and HIV antigens. We found that BCG-induced KLRG1+ NK cells exhibit significantly higher production of IFNγ, compared to KLRG1- cells, indicating their memory-like responses upon exposure to these antigens (p < 0.05). These findings may be important in regions of high burden of HIV and TB where BCG is routinely administered.
卡介苗（BCG）是唯一被批准用于预防结核分枝杆菌（MTB）的疫苗，不仅能预防结核病（TB），还能预防非相关感染。先天免疫细胞的“训练免疫”被认为是通过 BCG 获得这种广泛保护的机制之一。在这里，我们研究了卡介苗对自然杀伤（NK）细胞的影响，NK 细胞是一种关键的先天免疫细胞类型，以及它们对分枝杆菌和 HIV 抗原的后续反应。我们发现，与 KLRG1-细胞相比，BCG 诱导的 KLRG1+ NK 细胞产生 IFNγ 的水平显著升高，表明它们在接触这些抗原时表现出类似记忆的反应（p<0.05）。这些发现对于 HIV 和 TB 负担高的地区可能很重要，因为这些地区通常会接种卡介苗。
