Zhang Zhen, Yang Renlei, Zi Zhike, Liu Baohua
Shenzhen Key Laboratory for Systemic Aging and Intervention (SKL-SAI), School of Basic Medical Sciences, Shenzhen University Medical School, Shenzhen 518055, China.
Department of Plastic Surgery, Affiliated Friendship Plastic Surgery Hospital of Nanjing Medical University, Nanjing Medical University, Nanjing, China.
Trends Endocrinol Metab. 2025 May;36(5):440-458. doi: 10.1016/j.tem.2024.08.004. Epub 2024 Sep 2.
Aging is a major risk factor for a variety of diseases, thus, translation of aging research into practical applications is driven by the unmet need for existing clinical therapeutic options. Basic and translational research efforts are converging at a critical stage, yielding insights into how fundamental aging mechanisms are used to identify promising geroprotectors or therapeutics. This review highlights several research areas from a clinical perspective, including senescent cell targeting, alleviation of inflammaging, and optimization of metabolism with endogenous metabolites or precursors. Refining our understanding of these key areas, especially from the clinical angle, may help us to better understand and attenuate aging processes and improve overall health outcomes.
衰老是多种疾病的主要风险因素，因此，将衰老研究转化为实际应用是由现有临床治疗方案未满足的需求所驱动的。基础研究和转化研究工作在一个关键阶段汇聚，使人们深入了解如何利用基本的衰老机制来识别有前景的老年保护剂或治疗方法。本综述从临床角度突出了几个研究领域，包括靶向衰老细胞、减轻炎症衰老以及利用内源性代谢物或前体优化代谢。完善我们对这些关键领域的理解，尤其是从临床角度，可能有助于我们更好地理解和减轻衰老过程，并改善整体健康状况。
