Alzahrani Nadiah S, Aljahdali Bayan, Alhosain Aeshah, Alasmari Abeer Abdullah, Amna Touseef, Yousef Soha Mohamed
College of Science, Al-Baha University, Al Baha 65779, Saudi Arabia.
Department of Home Economics, College of Education, Najran University, Najran 11001, Saudi Arabia.
Pharmaceuticals (Basel). 2025 Aug 13;18(8):1196. doi: 10.3390/ph18081196.
Nonalcoholic fatty liver disease (NAFLD) associated with hyperlipidemia is a prevalent metabolic disorder, often triggered by high-fat diets (HFDs) in animal models. L. (AGs), rich in bioactive compounds, offers potential antioxidant and lipid-lowering benefits, making it a candidate for natural liver protection. This study evaluated the protective role of L. against hyperlipidemia-induced NAFLD in rats. Thirty male Wistar rats (150 ± 20 g, 10 weeks old) were split into five groups ( = 6 each). A control group received 0.25 mL 0.1% DMSO orally. Four HFD-fed groups included one with only DMSO (0.25 mL) and three supplemented with AG solution (0.25 mL) at 100, 200, or 500 mg/kg body weight. Treatments were given daily via gavage for two months. AGs' nutritional profile, serum lipids, liver function, and liver histology were analyzed. AGs contain 21.3% protein, 1.1% fat, 15% fiber, moderate vitamins (ascorbic acid, B-complex), and minerals (high potassium, calcium; low magnesium, phosphorus, sodium). AG-treated rats weighed less than the HFD controls. Unlike the control group (normal lipids, liver function, no steatosis), the HFD rats showed severe hyperlipidemia, liver dysfunction, and steatosis with fat changes. The AG groups exhibited dose-dependent improvements in lipids and liver function; the 200 mg/kg group had reduced fatty changes, and the 500 mg/kg group showed minimal hepatocyte fat. L. reduces hyperlipidemia and NAFLD progression in HFD-fed rats, which suggests its potential as a natural liver-protective agent.
与高脂血症相关的非酒精性脂肪性肝病（NAFLD）是一种常见的代谢紊乱疾病，在动物模型中通常由高脂饮食（HFD）引发。富含生物活性化合物的[具体乳酸菌名称未给出]（AGs）具有潜在的抗氧化和降脂益处，使其成为天然肝脏保护的候选物质。本研究评估了[具体乳酸菌名称未给出]对高脂血症诱导的大鼠非酒精性脂肪性肝病的保护作用。将30只雄性Wistar大鼠（150±20 g，10周龄）分为五组（每组n = 6）。对照组口服0.25 mL 0.1%二甲亚砜（DMSO）。四个高脂饮食喂养组中，一组仅给予DMSO（0.25 mL），另外三组分别补充100、200或500 mg/kg体重的AG溶液（0.25 mL）。通过灌胃每天给药两个月。分析了AGs的营养成分、血脂、肝功能和肝脏组织学。AGs含有21.3%的蛋白质、1.1%的脂肪、15%的纤维、适量的维生素（抗坏血酸、复合维生素B）和矿物质（高钾、钙；低镁、磷、钠）。AG处理的大鼠体重低于高脂饮食对照组。与对照组（血脂正常、肝功能正常、无脂肪变性）不同，高脂饮食大鼠表现出严重的高脂血症、肝功能障碍和脂肪变性伴脂肪变化。AG组在血脂和肝功能方面呈现剂量依赖性改善；200 mg/kg组脂肪变化减少，500 mg/kg组肝细胞脂肪最少。[具体乳酸菌名称未给出]可减轻高脂饮食喂养大鼠的高脂血症和非酒精性脂肪性肝病进展，这表明其作为天然肝脏保护剂的潜力。
