Department of Prevention and Health Care, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, 321000, Zhejiang, China.
Department of Oncology, The First Affiliated Hospital of Anhui Medical University, No.218 Jixi Road, Hefei, 230022, Anhui, China.
Nutr Diabetes. 2024 Sep 3;14(1):72. doi: 10.1038/s41387-024-00330-1.
The association of plastic additive mixture exposure with diabetes and the modifying effects of dietary antioxidants are unclear.
The data from the NHANES 2011-2018 were retrieved, and phthalates and organophosphate esters (OPEs) were selected as exposures. The coexposure effect was analyzed by the environmental risk score (ERS) and quantile g-computation. To mitigate any potential bias caused by using the internal weights, another version of ERS was constructed using the cross-validation approach. The level of dietary antioxidant intake was measured by the composite dietary antioxidant index (CDAI). The biological mechanism underlying the association was studied by the adverse outcome pathway (AOP) framework.
Fifteen chemicals (ten phthalates and five OPEs) were measured in 2824 adult participants. A higher ERS was significantly associated with an increased risk of diabetes (OR per 1-SD increment of ERS: 1.25, 95% CI: 1.13-1.39). This association apparently interacted with the CDAI level (OR: 1.83, 95% CI: 1.37-2.55; OR: 1.28, 95% CI: 1.15-1.45; P = 0.038). Moreover, quantile g-computation also revealed higher level of combined exposure was positively associated with diabetes (OR: 1.27, 95% CI: 1.05-2.87), and the addition of dietary antioxidants showed a null association (OR: 1.09, 95% CI: 0.85-2.34). The AOP study identified TCPP and TCEP as key chemicals that cause aberrant glucose metabolism and insulin signaling pathways and result in diabetes.
Coexposure to phthalates and OPEs is positively associated with diabetes, where an antioxidative diet plays a modifying role. Several potential mechanisms have been proposed by AOP framework.
塑料添加剂混合物暴露与糖尿病之间的关联以及膳食抗氧化剂的修饰作用尚不清楚。
检索了 2011-2018 年 NHANES 的数据，并选择邻苯二甲酸酯和有机磷酸酯 (OPEs) 作为暴露物。通过环境风险评分 (ERS) 和分位数 g 计算分析共暴露效应。为了减轻使用内部权重可能引起的任何潜在偏差，使用交叉验证方法构建了另一个版本的 ERS。膳食抗氧化剂摄入量的水平通过复合膳食抗氧化剂指数 (CDAI) 来衡量。使用不良结局途径 (AOP) 框架研究了关联的生物学机制。
在 2824 名成年参与者中测量了 15 种化学物质（十种邻苯二甲酸酯和五种 OPEs）。ERS 每增加 1-SD，糖尿病的风险显著增加（ERS 每增加 1-SD 的比值比：1.25，95%置信区间：1.13-1.39）。这种关联显然与 CDAI 水平相互作用（比值比：1.83，95%置信区间：1.37-2.55；比值比：1.28，95%置信区间：1.15-1.45；P=0.038）。此外，分位数 g 计算还显示，较高水平的联合暴露与糖尿病呈正相关（比值比：1.27，95%置信区间：1.05-2.87），而添加膳食抗氧化剂则显示出无关联（比值比：1.09，95%置信区间：0.85-2.34）。AOP 研究确定 TCPP 和 TCEP 是导致葡萄糖代谢和胰岛素信号通路异常并导致糖尿病的关键化学物质。
邻苯二甲酸酯和 OPEs 的共暴露与糖尿病呈正相关，而抗氧化饮食则起到修饰作用。AOP 框架提出了几种潜在的机制。
