School of Marine Sciences, Zhuhai Key Laboratory of Marine Bioresources and Environment, Guangdong Provincial Key Laboratory of Marine Resources and Coastal Engineering, Pearl River Estuary Marine Ecosystem Research Station, Ministry of Education, Sun Yat-Sen University, Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), Zhuhai 519082, China.
School of Marine Sciences, Zhuhai Key Laboratory of Marine Bioresources and Environment, Guangdong Provincial Key Laboratory of Marine Resources and Coastal Engineering, Pearl River Estuary Marine Ecosystem Research Station, Ministry of Education, Sun Yat-Sen University, Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), Zhuhai 519082, China.
J Hazard Mater. 2024 Mar 5;465:133389. doi: 10.1016/j.jhazmat.2023.133389. Epub 2024 Jan 5.
Plastic additives, such as organophosphate esters (OPEs) and phthalate esters (PAEs), are raising public concerns due to their widespread presence and potential health risks. Nonetheless, the occurrences and potential health risks of these additives in marine mammals remain limited. Here, we first investigated the accumulation patterns and potential risks of OPEs and metabolites of PAEs (mPAEs) in Indo-Pacific finless porpoises inhabiting the northern South China Sea (NSCS) during 2007-2020. The average hepatic concentrations of ∑OPEs and ∑mPAEs in the NSCS finless porpoises were 53.9 ± 40.7 and 98.6 ± 54.8 ng/g ww, respectively. The accumulation of mPAEs and OPEs in the finless porpoises is associated with the chemical structures of the compounds. ∑halogenated-OPEs were the most dominant category (62.6%) of ∑OPEs, followed by ∑aryl-OPEs (25.9%) and ∑nonhalogenated alkyl-OPEs (11.5%). The accumulation of mPAEs displayed a declining trend with increasing alkyl side chain length (C0-C10). Although the hepatic burden of mPAEs in finless porpoises was sex-independent, some OPEs, including TDCIPP, TBOEP, TCIPP, TCrP, TPHP, and TDBPP, exhibited significantly higher concentrations in adult males than in adult females. TDBPP, as a new-generation OPE, exhibited a gradual increase during the study period, suggesting that TDBPP should be prioritized for monitoring in the coastal regions of South China. The estimated hazard quotient indicated that almost all mPAEs and OPEs pose no hazard to finless porpoises, with only DEHP presenting potential health risks to both adult and juvenile finless porpoises.
塑料添加剂，如有机磷酸酯（OPEs）和邻苯二甲酸酯（PAEs），由于其广泛存在和潜在的健康风险而引起公众关注。然而，海洋哺乳动物中这些添加剂的存在和潜在健康风险仍然有限。在这里，我们首先研究了 2007-2020 年期间栖息在南海北部的印太江豚中 OPEs 和 PAEs 代谢物（mPAEs）的积累模式和潜在风险。南海江豚肝脏中∑OPEs 和∑mPAEs 的平均浓度分别为 53.9±40.7 和 98.6±54.8ng/g ww。江豚中 mPAEs 和 OPEs 的积累与化合物的化学结构有关。∑卤代-OPEs（62.6%）是∑OPEs 中最主要的类别，其次是∑芳基-OPEs（25.9%）和∑非卤代烷基-OPEs（11.5%）。mPAEs 的积累随着烷基侧链长度（C0-C10）的增加呈下降趋势。尽管 mPAEs 在江豚肝脏中的负担与性别无关，但一些 OPEs，包括 TDCIPP、TBOEP、TCIPP、TCrP、THHP 和 TDBPP，在成年雄性中的浓度明显高于成年雌性。TDBPP 作为新一代 OPE，在研究期间呈逐渐增加趋势，表明 TDBPP 应优先在华南沿海地区进行监测。估计的危害商数表明，几乎所有的 mPAEs 和 OPEs 对江豚没有危害，只有 DEHP 对成年和幼年江豚都存在潜在的健康风险。
