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采用病原微生物 DNA 高通量基因测序诊断结核分枝杆菌感染相关性腹膜透析相关性腹膜炎。

Pathogenic microorganism DNA high-throughput genetic sequencing to diagnose peritoneal dialysis-associated peritonitis due to Mycobacterium tuberculosis infection.

机构信息

Department of Nephrology, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, 010050, Inner Mongolia, PR China.

Department of Nephrology, No. 2 Hospital of Hohhot, Hohhot, PR China.

出版信息

BMC Nephrol. 2024 Sep 3;25(1):290. doi: 10.1186/s12882-024-03727-3.

Abstract

Peritoneal dialysis-associated peritonitis is a serious complication of peritoneal dialysis, and the prevention and treatment of this condition are important for improving the long-term survival and quality of life of patients. However, peritoneal dialysis-associated peritonitis due to Mycobacterium tuberculosis infection is relatively rare and not easily diagnosed. Here, we present a case of peritoneal dialysis-associated peritonitis caused by Mycobacterium tuberculosis identified by pathogenic microbial DNA high-throughput genetic sequencing. This case demonstrates that pathogenic microbial DNA high-throughput genetic sequencing could be used to improve the detection rate of pathogenic microorganisms in patients with complex conditions, thereby allowing for earlier initiation of treatment.

摘要

腹膜透析相关性腹膜炎是腹膜透析的严重并发症,预防和治疗该疾病对于提高患者的长期生存率和生活质量至关重要。然而,由结核分枝杆菌感染引起的腹膜透析相关性腹膜炎较为少见,且不易诊断。在这里,我们报告了一例由结核分枝杆菌引起的腹膜透析相关性腹膜炎病例,该病例通过病原微生物 DNA 高通量基因测序得以确诊。该病例表明,病原微生物 DNA 高通量基因测序可用于提高复杂情况下患者的病原体检测率,从而更早地开始治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/250f/11373123/b64d982f82ec/12882_2024_3727_Fig1_HTML.jpg

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