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脂肪干细胞分泌组在糖尿病足溃疡愈合中的研究进展及应用前景。

Research progress and application prospect of adipose-derived stem cell secretome in diabetes foot ulcers healing.

机构信息

Department of Plastic Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, 350005, China.

Department of Plastic Surgery, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350212, China.

出版信息

Stem Cell Res Ther. 2024 Sep 4;15(1):279. doi: 10.1186/s13287-024-03912-z.

DOI:10.1186/s13287-024-03912-z
PMID:39227906
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11373215/
Abstract

Diabetic foot ulcers (DFUs) are chronic wounds and one of the most common complications of diabetes, imposing significant physical and mental burdens on patients due to their poor prognosis and treatment efficacy. Adipose-derived stem cells (ADSCs) have been proven to promote wound healing, with studies increasingly attributing these beneficial effects to their paracrine actions. Consequently, research on ADSC secretome as a novel and promising alternative for DFU treatment has been extensively conducted. This article provides a comprehensive review of the mechanisms underlying refractory DFU wounds, the secretome of ADSCs, and its role in promoting wound healing in diabetes foot ulcers. And the review aims to provide reliable evidence for the clinical application of ADSC secretome in the treatment of refractory DFU wounds.

摘要

糖尿病足溃疡（DFUs）是慢性伤口，也是糖尿病最常见的并发症之一，由于其预后不良和治疗效果不佳，给患者带来了巨大的身心负担。脂肪来源的干细胞（ADSCs）已被证明可促进伤口愈合，越来越多的研究将这些有益作用归因于其旁分泌作用。因此，人们广泛研究 ADSC 分泌组作为 DFU 治疗的一种新型且有前途的替代方法。本文全面综述了难治性 DFU 创面的发生机制、ADSCs 的分泌组及其在促进糖尿病足溃疡愈合中的作用，旨在为 ADSC 分泌组在难治性 DFU 创面治疗中的临床应用提供可靠依据。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fad/11373215/e1d83747e289/13287_2024_3912_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fad/11373215/f29fd1e6c817/13287_2024_3912_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fad/11373215/e1d83747e289/13287_2024_3912_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fad/11373215/f29fd1e6c817/13287_2024_3912_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fad/11373215/e1d83747e289/13287_2024_3912_Fig2_HTML.jpg

相似文献

[1]
Research progress and application prospect of adipose-derived stem cell secretome in diabetes foot ulcers healing.

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[2]
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[3]
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[4]
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[5]
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[6]
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[7]
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[8]
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[9]
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[10]
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引用本文的文献

[1]
Multifunctional MOF microneedle patch with adsorbed exosomes for enhanced diabetic wound healing.

Mater Today Bio. 2025-7-11

[2]
The Effect of Adipose-Derived Stem Cell (ADSC)-Exos on the Healing of Autologous Skin Grafts in Miniature Pigs.

Int J Mol Sci. 2025-1-8

[3]
Ultrasmall Antioxidant Copper Nanozyme to Enhance Stem Cell Microenvironment for Promoting Diabetic Wound Healing.

Int J Nanomedicine. 2024-12-19

本文引用的文献

[1]
Localized, highly efficient secretion of signaling proteins by migrasomes.

Cell Res. 2024-8

[2]
Hypoxic adipose stem cell-derived exosomes carrying high-abundant USP22 facilitate cutaneous wound healing through stabilizing HIF-1α and upregulating lncRNA H19.

FASEB J. 2024-5-31

[3]
Synergistic large segmental bone repair by 3D printed bionic scaffolds and engineered ADSC nanovesicles: Towards an optimized regenerative microenvironment.

Biomaterials. 2024-7

[4]
Diabetes and infection: review of the epidemiology, mechanisms and principles of treatment.

Diabetologia. 2024-7

[5]
Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches.

J Extracell Vesicles. 2024-2

[6]
Neutrophil extracellular trap-related mechanisms in acne vulgaris inspire a novel treatment strategy with adipose-derived stem cells.

Sci Rep. 2024-1-17

[7]
Exosomes Derived from E2F1 Adipose-Derived Stem Cells Promote Skin Wound Healing via miR-130b-5p/TGFBR3 Axis.

Int J Nanomedicine. 2023

[8]
Mesenchymal stem cell-derived extracellular vesicles in skin wound healing: roles, opportunities and challenges.

Mil Med Res. 2023-8-17

[9]
Methylglyoxal Impairs the Pro-Angiogenic Ability of Mouse Adipose-Derived Stem Cells (mADSCs) via a Senescence-Associated Mechanism.

Cells. 2023-6-28

[10]
Diabetic Foot Ulcers: A Review.

JAMA. 2023-7-3

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