Department of Pediatric Cardiac Center, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
Beijing Anzhen Hospital, No 2 Anzhen Road Chaoyang District, Beijing, 100029, China.
J Cardiothorac Surg. 2024 Sep 3;19(1):512. doi: 10.1186/s13019-024-02981-8.
This study aims to present the midterm outcomes of surgical correction of the anomalous left coronary artery from the pulmonary artery (ALCAPA).
This is a retrospective study of patients undergoing anomalous origin of the LCA from the pulmonary artery repair between 2010 and 2019.
Forty-nine patients (20 boys and 29 girls) underwent ALCAPA repair. Patients were divided into two groups based on their age at ALCAPA repair: infant (< 1 year of age: n = 24) and non-infant ( ≧ 1 year of age: n = 25). Median age at time of repair was 23 months(7-60months). LCA reimplantation was performed in 47 patients, and Takeuchi repair was performed in 2 patients. Hospital mortality in the infant group was 8.2% (4 of 49). Infant group had significantly lower LVEF in pre-operation (p < 0.05), but there was not significantly different between the two groups about LVEF at discharge. The median follow-up duration was 43(18-85)months. The freedom from reoperation was not significantly different between two groups (infants vs. non-infants: 68.8% vs. 87.5% at 10 years; p = 0.096).
Surgical treatment of ALCAPA had an excellent early and midterm outcomes. Left ventricular dysfunction in pre-operation was the main risk of mortality in-hospital. The freedom from reoperation did not differ significantly between infant group and non-infant group.
本研究旨在介绍动脉发自肺动脉的左冠状动脉异常(ALCAPA)的中期手术矫正结果。
这是一项回顾性研究,纳入了 2010 年至 2019 年间接受异常起源的左冠状动脉修复术的患者。
49 名患者(20 名男孩和 29 名女孩)接受了 ALCAPA 修复术。根据 ALCAPA 修复时的年龄,患者分为两组:婴儿(<1 岁:n=24)和非婴儿(≧1 岁:n=25)。修复时的中位年龄为 23 个月(7-60 个月)。47 名患者行左冠状动脉再植入术,2 名患者行 Takeuchi 修复术。婴儿组的院内死亡率为 8.2%(4/49)。婴儿组的左心室射血分数(LVEF)在术前明显较低(p<0.05),但两组出院时的 LVEF 无明显差异。中位随访时间为 43(18-85)个月。两组之间的无再次手术率无显著差异(婴儿组与非婴儿组:10 年时分别为 68.8%和 87.5%;p=0.096)。
ALCAPA 的手术治疗具有极好的早期和中期结果。术前左心室功能障碍是院内死亡的主要危险因素。婴儿组和非婴儿组之间的无再次手术率无显著差异。