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左冠状动脉发自肺动脉畸形的手术矫正后的中期结果。

Midterm outcome after surgical correction of an anomaly of the left coronary artery from the pulmonary artery.

机构信息

Department of Pediatric Cardiac Center, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.

Beijing Anzhen Hospital, No 2 Anzhen Road Chaoyang District, Beijing, 100029, China.

出版信息

J Cardiothorac Surg. 2024 Sep 3;19(1):512. doi: 10.1186/s13019-024-02981-8.

DOI:10.1186/s13019-024-02981-8
PMID:39227974
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11370049/
Abstract

OBJECTIVE

This study aims to present the midterm outcomes of surgical correction of the anomalous left coronary artery from the pulmonary artery (ALCAPA).

METHODS

This is a retrospective study of patients undergoing anomalous origin of the LCA from the pulmonary artery repair between 2010 and 2019.

RESULTS

Forty-nine patients (20 boys and 29 girls) underwent ALCAPA repair. Patients were divided into two groups based on their age at ALCAPA repair: infant (< 1 year of age: n = 24) and non-infant ( ≧ 1 year of age: n = 25). Median age at time of repair was 23 months(7-60months). LCA reimplantation was performed in 47 patients, and Takeuchi repair was performed in 2 patients. Hospital mortality in the infant group was 8.2% (4 of 49). Infant group had significantly lower LVEF in pre-operation (p < 0.05), but there was not significantly different between the two groups about LVEF at discharge. The median follow-up duration was 43(18-85)months. The freedom from reoperation was not significantly different between two groups (infants vs. non-infants: 68.8% vs. 87.5% at 10 years; p = 0.096).

CONCLUSIONS

Surgical treatment of ALCAPA had an excellent early and midterm outcomes. Left ventricular dysfunction in pre-operation was the main risk of mortality in-hospital. The freedom from reoperation did not differ significantly between infant group and non-infant group.

摘要

目的

本研究旨在介绍动脉发自肺动脉的左冠状动脉异常(ALCAPA)的中期手术矫正结果。

方法

这是一项回顾性研究,纳入了 2010 年至 2019 年间接受异常起源的左冠状动脉修复术的患者。

结果

49 名患者(20 名男孩和 29 名女孩)接受了 ALCAPA 修复术。根据 ALCAPA 修复时的年龄,患者分为两组:婴儿(<1 岁:n=24)和非婴儿(≧1 岁:n=25)。修复时的中位年龄为 23 个月(7-60 个月)。47 名患者行左冠状动脉再植入术,2 名患者行 Takeuchi 修复术。婴儿组的院内死亡率为 8.2%(4/49)。婴儿组的左心室射血分数(LVEF)在术前明显较低(p<0.05),但两组出院时的 LVEF 无明显差异。中位随访时间为 43(18-85)个月。两组之间的无再次手术率无显著差异(婴儿组与非婴儿组:10 年时分别为 68.8%和 87.5%;p=0.096)。

结论

ALCAPA 的手术治疗具有极好的早期和中期结果。术前左心室功能障碍是院内死亡的主要危险因素。婴儿组和非婴儿组之间的无再次手术率无显著差异。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f73/11370049/ae2aeba9a14a/13019_2024_2981_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f73/11370049/c86d7a1fa4b8/13019_2024_2981_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f73/11370049/ae2aeba9a14a/13019_2024_2981_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f73/11370049/c86d7a1fa4b8/13019_2024_2981_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f73/11370049/ae2aeba9a14a/13019_2024_2981_Fig2_HTML.jpg

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本文引用的文献

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Anomalous Left Coronary Artery from the Pulmonary Artery: How to Diagnose and Treat.起源于肺动脉的异常左冠状动脉:如何诊断与治疗
J Pers Med. 2023 Oct 31;13(11):1561. doi: 10.3390/jpm13111561.
2
Anomalous left coronary artery from the pulmonary artery: Outcomes and management of mitral valve.起源于肺动脉的异常左冠状动脉:二尖瓣的治疗结果与处理
Front Cardiovasc Med. 2022 Oct 6;9:953420. doi: 10.3389/fcvm.2022.953420. eCollection 2022.
3
Long-term Outcomes of Children Operated on for Anomalous Left Coronary Artery From the Pulmonary Artery.
左冠状动脉异常起源于肺动脉患儿的长期预后。
Ann Thorac Surg. 2022 Apr;113(4):1223-1230. doi: 10.1016/j.athoracsur.2021.07.053. Epub 2021 Aug 19.
4
Anomalous left coronary artery from the pulmonary artery repair outcomes: Preoperative mitral regurgitation persists in the follow-up.肺动脉起源异常的左冠状动脉修复结果:术前二尖瓣反流在随访中持续存在。
J Card Surg. 2021 Feb;36(2):530-535. doi: 10.1111/jocs.15247. Epub 2020 Dec 16.
5
Intermediate Outcomes After Repair of Anomalous Left Coronary Artery From the Pulmonary Artery.左冠状动脉异常起源于肺动脉修复术后的中期结果。
Ann Thorac Surg. 2021 Oct;112(4):1307-1315. doi: 10.1016/j.athoracsur.2020.06.130. Epub 2020 Sep 20.
6
Diagnosis and treatment of abnormal left coronary artery originating from the pulmonary artery: A single-center experience.起源于肺动脉的异常左冠状动脉的诊断与治疗:单中心经验
Anatol J Cardiol. 2019 Nov;22(6):325-331. doi: 10.14744/AnatolJCardiol.2019.30670.
7
Mid-Term Outcome for Anomalous Origin of the Left Coronary Artery From the Pulmonary Artery.左冠状动脉异常起源于肺动脉的中期结果。
Heart Lung Circ. 2020 May;29(5):766-771. doi: 10.1016/j.hlc.2019.04.018. Epub 2019 May 24.
8
Long-term outcome after anomalous left coronary artery from the pulmonary artery repair: a 40-year single-centre experience.动脉导管未闭结扎术后残余分流的介入治疗:40 年单中心经验。
Eur J Cardiothorac Surg. 2018 Apr 1;53(4):732-739. doi: 10.1093/ejcts/ezx407.
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Outcomes from anomalous origin of the left coronary artery from the pulmonary artery repair: Long-term complications in relation to residual myocardial abnormalities.肺动脉起源的左冠状动脉异常修复的结果:与残余心肌异常相关的长期并发症。
J Cardiol. 2017 Nov;70(5):498-503. doi: 10.1016/j.jjcc.2017.03.008. Epub 2017 Apr 17.
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