Department of Infectious Disease, Xiamen Children's Hospital/Children's Hospital of Fudan University at Xiamen/State-level Regional Children's Medical Center, Xiamen, Fujian, China.
Department of Clinical Laboratory, Xiamen Children's Hospital/Children's Hospital of Fudan University at Xiamen/State-level Regional Children's Medical Center, Xiamen, Fujian, China.
J Med Virol. 2024 Sep;96(9):e29888. doi: 10.1002/jmv.29888.
This study investigated the roles of P-selectin and Clara cell secretory protein 16 (CC16) levels in the pathogenesis of severe adenovirus (ADV) pneumonia in children and evaluated their ability to predict disease. Fifty-one children (age, 1-5 years) with ADV pneumonia who were admitted to Xiamen Children's Hospital were included in this study and divided into the mild group (24 patients) and severe group (27 patients). A control group comprising healthy children of the same age who underwent routine physical examinations during the same period (30 patients) was also included. The univariate analysis demonstrated that the levels of the white blood cell count and C-reactive protein, procalcitonin, d-dimer, and P-selectin were increased in a severe group compared with a mild group, while CC16 levels were significantly decreased (p < 0.05). The logistic regression analysis revealed that P-selectin and CC16 levels were independent risk factors for severe ADV pneumonia in children. The areas under the ROC curves suggested that P-selectin and CC16 exhibited high predictive value for severe ADV pneumonia. P-selectin values more than 898.58 pg/mL and CC16 values less than 11.355 ng/mL predicted severe ADV pneumonia. P-selectin and CC16 levels are correlated with the severity of ADV pneumonia in children.
本研究探讨了 P 选择素和 Clara 细胞分泌蛋白 16（CC16）水平在儿童重症腺病毒（ADV）肺炎发病机制中的作用，并评估了它们预测疾病的能力。本研究纳入了 51 例因 ADV 肺炎入住厦门儿童医院的患儿，分为轻症组（24 例）和重症组（27 例）。同期接受常规体检的 30 例健康同龄儿童作为对照组。单因素分析显示，重症组患儿的白细胞计数和 C 反应蛋白、降钙素原、D-二聚体和 P 选择素水平较轻症组升高，而 CC16 水平明显降低（p<0.05）。Logistic 回归分析显示，P 选择素和 CC16 水平是儿童重症 ADV 肺炎的独立危险因素。ROC 曲线下面积提示 P 选择素和 CC16 对重症 ADV 肺炎具有较高的预测价值。P-选择素值>898.58 pg/mL 且 CC16 值<11.355 ng/mL 预测重症 ADV 肺炎。P 选择素和 CC16 水平与儿童 ADV 肺炎的严重程度相关。
