Department of Oncology and Gerontology, First Affiliated Hospital, Xi'an Medical University, Xi'an, People's Republic of China.
Department of Respiratory Medicine, Jining No.1 People's Hospital, Jining, People's Republic of China.
Int J Chron Obstruct Pulmon Dis. 2020 Mar 2;15:461-470. doi: 10.2147/COPD.S230323. eCollection 2020.
The aim of this study was to reveal the correlations between serum concentration of Clara cell secretory protein (CC16) and clinical parameters of stable chronic obstructive pulmonary disease (COPD).
Serum concentration of CC16 was determined by enzyme-linked immunosorbent assay (ELISA). The correlations between serum concentration of CC16 and clinical parameters was performed by linear correlation analysis and multiple linear regression analysis. The sensitivity and specificity of serum CC16 for differential diagnosis of COPD were determined by receiver operator characteristic curve (ROC).
The serum concentration of CC16 was down-regulated in stable COPD patients compared with healthy control group (p < 0.05). The decreased serum CC16 was negatively related to smoking (p < 0.05), GOLD grading (p < 0.005), mMRC score (p < 0.05) and medical history (p < 0.05) of patients, but positively correlated with pulmonary function (p < 0.05). The smoking, FEV1/FVC values, COPD grading and mMRC scores all affected the concentration of CC16 (p < 0.05). The decreased CC16 was an independent risk factor in the process of deterioration of lung function. The sensitivity and specificity of serum CC16 for identifying COPD reached to 65.3% and 75%.
Decreased serum concentration of CC16 correlated with the disease progression of COPD, suggesting that it can be used as an indicator contributing to the diagnosis and assessment of COPD.
本研究旨在揭示 Clara 细胞分泌蛋白（CC16）血清浓度与稳定期慢性阻塞性肺疾病（COPD）临床参数之间的相关性。
采用酶联免疫吸附试验（ELISA）测定 CC16 血清浓度。通过线性相关分析和多元线性回归分析，研究 CC16 血清浓度与临床参数之间的相关性。通过接收者操作特征曲线（ROC）确定血清 CC16 对 COPD 鉴别诊断的灵敏度和特异性。
与健康对照组相比，稳定期 COPD 患者的 CC16 血清浓度降低（p < 0.05）。降低的血清 CC16 与吸烟（p < 0.05）、GOLD 分级（p < 0.005）、mMRC 评分（p < 0.05）和病史（p < 0.05）呈负相关，但与肺功能（p < 0.05）呈正相关。吸烟、FEV1/FVC 值、COPD 分级和 mMRC 评分均影响 CC16 的浓度（p < 0.05）。降低的 CC16 是肺功能恶化过程中的独立危险因素。血清 CC16 对 COPD 的识别具有 65.3%的灵敏度和 75%的特异性。
CC16 血清浓度降低与 COPD 的疾病进展相关，提示其可作为 COPD 诊断和评估的指标。
