Staritz M, Poralla T, Dormeyer H H, Meyer zum Büschenfelde K H
Gastroenterology. 1985 Jun;88(6):1807-11. doi: 10.1016/0016-5085(85)90004-6.
Recently, glyceryl trinitrate was shown to effectively dilate the smooth muscle of the sphincter of Oddi. This information was applied to endoscopic therapy of bile duct stones. In 21 patients a total of 32 common bile duct stones, 6-12 mm (means = 8.7 mm) in diameter, were removed through the intact sphincter after its medical dilation by administration of 1.2-3.6 mg glyceryl trinitrate. Thirty of 32 stones could be extracted without difficulty. The remaining two concrements had to be crushed by endoscopic mechanical lithotripsy before removal. No complications were observed during or after the procedure. Follow-up manometric examinations showed the papillary function to be well preserved. We therefore consider this new, safe, and easy method to be the treatment of choice for the removal of small- and medium-sized bile duct stones.
最近，已证实硝酸甘油能有效扩张Oddi括约肌的平滑肌。这一信息已应用于胆管结石的内镜治疗。21例患者共有32枚直径为6 - 12毫米（平均 = 8.7毫米）的胆总管结石，在通过给予1.2 - 3.6毫克硝酸甘油进行药物扩张后，经完整的括约肌被取出。32枚结石中有30枚能够顺利取出。其余两枚结石在取出前必须通过内镜机械碎石术粉碎。术中及术后均未观察到并发症。随访测压检查显示乳头功能保存良好。因此，我们认为这种新的、安全且简便的方法是治疗中小型胆管结石的首选方法。
