Yazit Noor Anisah Abu, Juliana Norsham, Hafidz Kamilah Muhammad, Aziz Nur Adilah Shuhada Abd, Maluin Sofwatul Mokhtarah, Azmani Sahar, Teng Nur Islami Mohd Fahmi, Das Srijit, Kadiman Suhaini
Faculty Medicine and Health Science, Universiti Sains Islam Malaysia, 71800 Nilai, Negeri Sembilan, Malaysia.
Department of Anaesthesia and Intensive Care Unit, Institut Jantung Negara, 50400 Kuala Lumpur, Malaysia.
Rev Cardiovasc Med. 2024 Aug 1;25(8):273. doi: 10.31083/j.rcm2508273. eCollection 2024 Aug.
Mini-mental State Examination (MMSE) is widely accepted clinically for postoperative cognitive dysfunction (POCD) assessment. This study aims to investigate the post-operative cognitive changes among high-risk cardiothoracic patients and establish a standardised approach to post-surgery cognitive assessment.
This is a prospective cohort study, where cognitive assessments were done 1-day before surgery, at discharge, and during 6 weeks of follow-up. Sample size calculation, accounting for an estimated 20% dropout rate, determined a minimum of 170 subjects were required for the study. Reduction of MMSE score of more than 2.5 was considered as having POCD. Score differences between groups were analysed using -test and analysis of variance (ANOVA), while consistency between tools was analysed using correlation and regression.
A total of 188 patients completed the study, with a POCD prevalence of 20.2% and 6.9% at discharge and at the 6 week follow up, respectively. All cognitive tools show a significant difference between preoperative and postoperative scores. All tests show a significant moderate correlation with MMSE.
In conclusion, it is imperative to employ a battery of cognitive assessments to evaluate cognitive changes comprehensively.
简易精神状态检查表（MMSE）在临床上被广泛用于评估术后认知功能障碍（POCD）。本研究旨在调查高危心胸外科患者术后的认知变化，并建立一种标准化的术后认知评估方法。
这是一项前瞻性队列研究，在手术前1天、出院时以及随访6周期间进行认知评估。考虑到估计20%的失访率进行样本量计算，确定该研究至少需要170名受试者。MMSE评分降低超过2.5分被视为患有POCD。使用t检验和方差分析（ANOVA）分析组间评分差异，同时使用相关性和回归分析工具之间的一致性。
共有188名患者完成了研究，出院时和随访6周时的POCD患病率分别为20.2%和6.9%。所有认知工具在术前和术后评分之间均显示出显著差异。所有测试与MMSE均显示出显著的中度相关性。
总之，必须采用一系列认知评估来全面评估认知变化。
