Sumana M, Saraswathi S, Mukhopadhyay Amita, Debata Ipsita, Ranganath T S
Department of Community Medicine, Bangalore Medical College and Research Institute, Bengaluru, Karnataka, India.
Department of Hospital and Health Management, Institute of Health Management Research Bangalore, Bengaluru, Karnataka, India.
J Family Med Prim Care. 2024 Aug;13(8):3129-3134. doi: 10.4103/jfmpc.jfmpc_23_24. Epub 2024 Jul 26.
The annual incidence cases report depicts India as having the highest tuberculosis (TB) burden globally. Following a programmatic change, the daily fixed-dose combination (FDC) anti-TB treatment regimens were introduced by the Indian government's National Tuberculosis Elimination Program (NTEP).
The aim of the study was to assess the treatment outcomes among drug-sensitive pulmonary TB patients receiving daily FDC drugs and the associated factors influencing the treatment outcomes.
A prospective study was conducted among 300 drug-sensitive pulmonary TB cases in the Bruhat Bengaluru Mahanagara Palike (BBMP) area.
The TB units and designated microscopic centers (DMCs) were selected by multistage random sampling. Data were collected through a pre-tested and semi-structured questionnaire. Patients were followed up until treatment completion.
Data were compiled and analyzed using IBM Statistical Package for Social Sciences (SPSS) statistics version 20.0. Descriptive statistics and the Chi-square test were used for interpretation. A -value less than 0.05 was considered statistically significant.
Around 86.33% of patients were cured, 4% had completed treatment, and 1% had treatment failure. Older age, human immunodeficiency virus (HIV) reactive status, alcohol intake, tobacco use, and migrants were associated with poor outcomes.
The daily FDC regimen had better outcomes than intermittent regimens. Smokers, alcoholics, migrants, and patients with co-morbidity need to be given priority in management as they are prone to poorer outcomes.
年度发病病例报告显示，印度是全球结核病负担最高的国家。在方案调整后，印度政府的国家结核病消除计划（NTEP）引入了每日固定剂量联合（FDC）抗结核治疗方案。
本研究的目的是评估接受每日FDC药物治疗的药物敏感型肺结核患者的治疗效果以及影响治疗效果的相关因素。
在班加罗尔市市政局（BBMP）地区对300例药物敏感型肺结核病例进行了一项前瞻性研究。
通过多阶段随机抽样选择结核病治疗单位和指定显微镜检查中心（DMC）。通过预先测试的半结构化问卷收集数据。对患者进行随访直至治疗结束。
使用IBM社会科学统计软件包（SPSS）20.0版对数据进行整理和分析。采用描述性统计和卡方检验进行解释。P值小于0.05被认为具有统计学意义。
约86.33%的患者治愈，4%完成治疗，1%治疗失败。年龄较大、人类免疫缺陷病毒（HIV）反应状态、饮酒、吸烟和移民与治疗效果不佳有关。
每日FDC方案的治疗效果优于间歇方案。吸烟者、酗酒者、移民和合并症患者在管理中需要优先考虑，因为他们更容易出现较差的治疗效果。
