符合强力霉素暴露后预防条件人群中的四环素耐药性及共耐药性
Tetracycline Resistance and Co-resistance in a Doxy-PEP-Eligible Population.
作者信息
Mittelstaedt Rachel, Kanjilal Sanjat, Helekal David, Robbins Gregory K, Grad Yonatan H
机构信息
Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA.
出版信息
medRxiv. 2024 Aug 22:2024.08.22.24312434. doi: 10.1101/2024.08.22.24312434.
Abstract
In infections in men eligible for doxycycline post-exposure prophylaxis (doxy-PEP), tetracycline non-susceptibility is more prevalent than in the overall population and is associated with resistance to trimethoprim-sulfamethoxazole and clindamycin. Doxy-PEP may select for multi-drug resistance, underscoring the importance of surveillance.
摘要
在有资格接受多西环素暴露后预防（多西环素-PEP）的男性感染中，四环素不敏感性比总体人群中更为普遍，并且与对甲氧苄啶-磺胺甲恶唑和克林霉素的耐药性相关。多西环素-PEP可能会选择多重耐药性，这突出了监测的重要性。
相似文献
1
Tetracycline Resistance and Co-resistance in a Doxy-PEP-Eligible Population.符合强力霉素暴露后预防条件人群中的四环素耐药性及共耐药性
medRxiv. 2024 Aug 22:2024.08.22.24312434. doi: 10.1101/2024.08.22.24312434.
2
Staphylococcus aureus Tetracycline Resistance and Co-resistance in a Doxycycline Postexposure Prophylaxis-Eligible Population.多西环素暴露后预防适用人群中的金黄色葡萄球菌四环素耐药性及共耐药性
J Infect Dis. 2025 Apr 15;231(4):e708-e712. doi: 10.1093/infdis/jiae634.
3
Potential Impact of Doxycycline Post-Exposure Prophylaxis on Tetracycline Resistance in Neisseria gonorrhoeae and Colonization with Tetracycline-Resistant Staphylococcus aureus and Group A Streptococcus.多西环素暴露后预防对淋病奈瑟菌四环素耐药性以及耐四环素金黄色葡萄球菌和A组链球菌定植的潜在影响。
Clin Infect Dis. 2025 Feb 28. doi: 10.1093/cid/ciaf089.
4
Doxycycline post-exposure prophylaxis for sexually transmitted infections impacts the gut antimicrobial resistome.多西环素用于性传播感染的暴露后预防会影响肠道抗菌药物耐药组。
Res Sq. 2024 Apr 17:rs.3.rs-4243341. doi: 10.21203/rs.3.rs-4243341/v1.
5
Impact of doxycycline post-exposure prophylaxis for sexually transmitted infections on the gut microbiome and antimicrobial resistome.多西环素暴露后预防性治疗性传播感染对肠道微生物群和抗菌药物耐药组的影响。
Nat Med. 2025 Jan;31(1):207-217. doi: 10.1038/s41591-024-03274-2. Epub 2024 Oct 3.
6
Is doxycycline post-exposure prophylaxis being utilised in Germany? Insights from an online survey among German men who have sex with men.德国是否在使用多西环素进行暴露后预防？对德国男同性恋者的一项在线调查结果
Infection. 2025 Feb;53(1):61-70. doi: 10.1007/s15010-024-02321-x. Epub 2024 Jul 23.
7
Australian consensus statement on doxycycline post-exposure prophylaxis (doxy-PEP) for the prevention of syphilis, chlamydia and gonorrhoea among gay, bisexual and other men who have sex with men.澳大利亚关于多西环素暴露后预防（doxy-PEP）用于预防男同性恋、双性恋和其他与男性发生性关系的男性中的梅毒、衣原体和淋病的共识声明。
Med J Aust. 2024 Apr 15;220(7):381-386. doi: 10.5694/mja2.52258. Epub 2024 Mar 13.
8
Doxycycline post exposure prophylaxis could select for cross-resistance to other antimicrobials in various pathogens: An in silico analysis.多西环素暴露后预防可能会使各种病原体对其他抗菌药物产生交叉耐药性：一项计算机分析。
Int J STD AIDS. 2023 Nov;34(13):962-968. doi: 10.1177/09564624231190108. Epub 2023 Jul 19.
9
Doxycycline to prevent bacterial sexually transmitted infections in the USA: final results from the DoxyPEP multicentre, open-label, randomised controlled trial and open-label extension.多西环素预防美国细菌性性传播感染：DoxyPEP多中心、开放标签、随机对照试验及开放标签扩展研究的最终结果
Lancet Infect Dis. 2025 Mar 24. doi: 10.1016/S1473-3099(25)00085-4.
10
Doxycycline post-exposure prophylaxis for preventing bacterial sexually transmitted infections (STIs): Are clinical providers supportive?多西环素暴露后预防细菌性性传播感染：临床医疗服务提供者是否支持？
Int J STD AIDS. 2025 Mar;36(4):297-303. doi: 10.1177/09564624241309433. Epub 2024 Dec 24.
本文引用的文献
1
CDC Clinical Guidelines on the Use of Doxycycline Postexposure Prophylaxis for Bacterial Sexually Transmitted Infection Prevention, United States, 2024.美国疾病预防控制中心 2024 年关于使用多西环素进行细菌性性传播感染预防的暴露后预防临床指南。
MMWR Recomm Rep. 2024 Jun 6;73(2):1-8. doi: 10.15585/mmwr.rr7302a1.
2
Doxycycline post-exposure prophylaxis could theoretically select for resistance to various antimicrobials in 19 pathobionts: an in silico analysis.多西环素暴露后预防理论上可能会在19种共生病原菌中选择出对多种抗菌药物的耐药性：一项计算机模拟分析。
Int J Infect Dis. 2024 May;142:106974. doi: 10.1016/j.ijid.2024.02.017. Epub 2024 Feb 21.
3
Estimating changes in antibiotic consumption in the USA with the introduction of doxycycline post-exposure prophylaxis.通过引入多西环素暴露后预防措施来估算美国抗生素消费量的变化。
Lancet Microbe. 2024 Jan;5(1):e9. doi: 10.1016/S2666-5247(23)00314-2. Epub 2023 Oct 23.
4
Postexposure Doxycycline to Prevent Bacterial Sexually Transmitted Infections.暴露后多西环素预防细菌性性传播感染。
N Engl J Med. 2023 Apr 6;388(14):1296-1306. doi: 10.1056/NEJMoa2211934.
5
Alterations of human skin microbiome and expansion of antimicrobial resistance after systemic antibiotics.全身用抗生素后人类皮肤微生物组的改变和抗菌药物耐药性的扩展。
Sci Transl Med. 2021 Dec 22;13(625):eabd8077. doi: 10.1126/scitranslmed.abd8077.
6
Origin and proliferation of multiple-drug resistance in bacterial pathogens.细菌病原体中多重耐药性的起源与增殖。
Microbiol Mol Biol Rev. 2015 Mar;79(1):101-16. doi: 10.1128/MMBR.00039-14.
7
Clinical practice guidelines by the infectious diseases society of america for the treatment of methicillin-resistant Staphylococcus aureus infections in adults and children.美国传染病学会发布的耐甲氧西林金黄色葡萄球菌感染成人和儿童治疗临床实践指南。
Clin Infect Dis. 2011 Feb 1;52(3):e18-55. doi: 10.1093/cid/ciq146. Epub 2011 Jan 4.
8
Risk factors for community-associated methicillin-resistant Staphylococcus aureus skin infections among HIV-positive men who have sex with men.男男性行为的HIV阳性者中社区获得性耐甲氧西林金黄色葡萄球菌皮肤感染的危险因素
Clin Infect Dis. 2005 May 15;40(10):1529-34. doi: 10.1086/429827. Epub 2005 Apr 13.
Zotero 插件