Oluwo Aderonke O, Lawal Mary A, Mabogunje Cecilia A, Okurame Olubunmi T
Dental Division, Massey Street Children's Hospital, Lagos, Nigeria.
Medical Division, Massey Street Children's Hospital, Lagos, Nigeria.
Afr J Lab Med. 2024 Aug 20;13(1):2362. doi: 10.4102/ajlm.v13i1.2362. eCollection 2024.
The impact of antimicrobial resistance on children living in resource-limited countries has been underreported, despite its established global threat.
This retrospective study aimed to describe the trend of antibiotic susceptibility in the paediatric age group.
Sensitivity test report data consisting of 300 paediatric patients aged 18 hours to 192 months were retrieved from the microbiology laboratory records at a state-owned children's hospital in Nigeria over a period of 4 months starting from December 2021 to March 2022. Five genera ( spp., spp., and spp.) were cultured as recommended by the Clinical Laboratory Standard Institute, using the Kirby Bauer disc diffusion method. Antimicrobial susceptibility testing was carried out on isolates using 15 different antibiotics.
was the most frequent pathogen isolated 32.1% (50/156) and spp. was the least frequent pathogen isolated 7.1% (11/156) in all samples. The isolates with the highest rate of resistance to the tested antibiotics were 32.1% (50/156), 28.2% (44/156) and spp. 20.5% (32/156). Isolates in all age groups were more resistant to ampicillin, amoxicillin + clavulanic acid, cefuroxime and cefepime.
Antibiotic resistance is high, especially the younger Nigerian children. Strict antibiotic protocols should be adhered to especially in the use of empirical antibiotic therapy in hospitals.
Our study reveals a higher trend of antibiotic resistance, especially in younger children. It further shows that the pathogens are most resistant to the most available empirical antibiotics in Nigeria.
尽管抗菌素耐药性已成为全球公认的威胁，但关于其对生活在资源有限国家儿童的影响的报道却很少。
这项回顾性研究旨在描述儿科年龄组抗生素敏感性的趋势。
从尼日利亚一家国有儿童医院的微生物实验室记录中检索了2021年12月至2022年3月期间4个月内300名年龄在18小时至192个月的儿科患者的药敏试验报告数据。按照临床实验室标准协会的建议，使用 Kirby Bauer 纸片扩散法培养了五个属（ 属、 属、 属和 属）。对分离株使用15种不同的抗生素进行药敏试验。
在所有样本中， 是最常分离出的病原体，占32.1%（50/156），而 属是最不常分离出的病原体，占7.1%（11/156）。对测试抗生素耐药率最高的分离株是 ，占32.1%（50/156）， 占28.2%（44/156）， 属占20.5%（32/156）。所有年龄组的分离株对氨苄西林、阿莫西林 + 克拉维酸、头孢呋辛和头孢吡肟的耐药性更高。
抗生素耐药性很高，尤其是尼日利亚的年幼儿童。应严格遵守抗生素使用规范，特别是在医院使用经验性抗生素治疗时。
我们的研究揭示了抗生素耐药性的更高趋势，尤其是在年幼儿童中。它进一步表明，病原体对尼日利亚最常用的经验性抗生素耐药性最强。
