新生儿重症监护病房的抗菌药物耐药性防治：新生儿脓毒症中抗生素的合理使用
Fighting Antimicrobial Resistance in Neonatal Intensive Care Units: Rational Use of Antibiotics in Neonatal Sepsis.
作者信息
Rallis Dimitrios, Giapros Vasileios, Serbis Anastasios, Kosmeri Chrysoula, Baltogianni Maria
机构信息
Neonatal Intensive Care Unit, School of Medicine, University of Ioannina, 451 10 Ioannina, Greece.
Department of Paediatrics, School of Medicine, University of Ioannina, 451 10 Ioannina, Greece.
出版信息
Antibiotics (Basel). 2023 Mar 3;12(3):508. doi: 10.3390/antibiotics12030508.
Abstract
Antibiotics are the most frequently prescribed drugs in neonatal intensive care units (NICUs) due to the severity of complications accompanying neonatal sepsis. However, antimicrobial drugs are often used inappropriately due to the difficulties in diagnosing sepsis in the neonatal population. The reckless use of antibiotics leads to the development of resistant strains, rendering multidrug-resistant pathogens a serious problem in NICUs and a global threat to public health. The aim of this narrative review is to provide a brief overview of neonatal sepsis and an update on the data regarding indications for antimicrobial therapy initiation, current guidance in the empirical antimicrobial selection and duration of therapy, and indications for early discontinuation.
摘要
由于新生儿败血症伴随的并发症严重，抗生素是新生儿重症监护病房（NICUs）中最常使用的药物。然而，由于新生儿群体败血症诊断困难，抗菌药物常常使用不当。抗生素的滥用导致耐药菌株的产生，使多重耐药病原体成为新生儿重症监护病房中的一个严重问题，并对全球公共卫生构成威胁。本叙述性综述的目的是简要概述新生儿败血症，并更新有关开始抗菌治疗的指征、经验性抗菌药物选择和治疗持续时间的当前指南以及早期停药指征的数据。
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