Edwards Madeline M, Rubin Jonathan E, Huang Chengcheng
Center for the Neural Basis of Cognition, Pittsburgh, PA, USA.
Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA, USA.
bioRxiv. 2024 Aug 24:2024.08.23.609417. doi: 10.1101/2024.08.23.609417.
Several inhibitory interneuron subtypes have been identified as critical in regulating sensory responses. However, the specific contribution of each interneuron subtype remains uncertain. In this work, we explore the contributions of cell-type specific activity and synaptic connections to dynamics of a spatially organized spiking neuron network. We find that the firing rates of the somatostatin (SOM) interneurons align closely with the level of network synchrony irrespective of the target of modulatory input. Further analysis reveals that inhibition from SOM to parvalbumin (PV) interneurons must be limited to allow gradual transitions from asynchrony to synchrony and that the strength of recurrent excitation onto SOM neurons determines the level of synchrony achievable in the network. Our results are consistent with recent experimental findings on cell-type specific manipulations. Overall, our results highlight common dynamic regimes achieved across modulations of different cell populations and identify SOM cells as the main driver of network synchrony.
几种抑制性中间神经元亚型已被确定在调节感觉反应中起关键作用。然而，每种中间神经元亚型的具体贡献仍不确定。在这项工作中，我们探索了细胞类型特异性活动和突触连接对空间组织的脉冲神经元网络动态的贡献。我们发现，无论调节输入的目标如何，生长抑素（SOM）中间神经元的放电率都与网络同步水平密切相关。进一步分析表明，从SOM到小白蛋白（PV）中间神经元的抑制必须受到限制，以允许从异步到同步的逐渐转变，并且SOM神经元上的反复兴奋强度决定了网络中可实现的同步水平。我们的结果与最近关于细胞类型特异性操作的实验结果一致。总体而言，我们的结果突出了不同细胞群体调制所实现的共同动态模式，并确定SOM细胞是网络同步的主要驱动因素。
