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甲氨基阿维菌素苯甲酸盐中毒综述

Review of Emamectin Benzoate Poisoning.

作者信息

Pan Chi-Syuan, Chen Chun-Hung, Mu Han-Wei, Yang Kai-Wei

机构信息

Department of Emergency Medicine Division of Toxicology China Medical University Hospital, Taichung City Taiwan.

出版信息

J Acute Med. 2024 Sep 1;14(3):101-107. doi: 10.6705/j.jacme.202409_14(3).0001.

Abstract

Emamectin Benzoate, a potent pesticide extensively used in agriculture, has raised concerns due to its potential for severe poisoning. While its safety in mammals is attributed to limited blood-brain barrier penetration and reduced affinity for specific channels, Emamectin Benzoate Poisoning can unexpectedly manifest with severe symptoms. Predominantly resulting from intentional ingestion, clinical presentations involve central nervous system depression, respiratory distress, gastrointestinal symptoms, and sore throat. Formulation solvents enhance toxicity, leading to corrosive injuries and metabolic imbalances. Skin contact induces irritation. Diagnosis relies on clinical evaluation, lacking specific laboratory data. Treatment lacks a designated antidote; hence, decontamination and cautious symptomatic management play pivotal roles. Severe cases require vigilant monitoring, with intensive care unit admission calling for altered consciousness and respiratory distress.

摘要

甲氨基阿维菌素苯甲酸盐是一种广泛应用于农业的强力杀虫剂,因其具有严重中毒的可能性而引发了人们的关注。虽然它在哺乳动物中的安全性归因于其对血脑屏障的穿透有限以及对特定通道的亲和力降低,但甲氨基阿维菌素苯甲酸盐中毒可能会意外地出现严重症状。主要由故意摄入引起,临床表现包括中枢神经系统抑制、呼吸窘迫、胃肠道症状和喉咙痛。制剂溶剂会增强毒性,导致腐蚀性损伤和代谢失衡。皮肤接触会引起刺激。诊断依赖于临床评估,缺乏特定的实验室数据。治疗缺乏指定的解毒剂;因此,去污和谨慎的对症处理起着关键作用。严重病例需要密切监测,对于意识改变和呼吸窘迫的情况需要入住重症监护病房。

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本文引用的文献

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