Recent advances in PEDOT/PProDOT-derived nano biosensors: engineering nano assemblies for fostering advanced detection platforms for biomolecule detection.

With the recent unprecedented emergence of a global pandemic, unknown diseases and new metabolic patterns expressing serious health issues, the requirement to develop new diagnostic tools, therapeutic solutions, and healthcare and environmental monitoring systems are significantly higher in the present situation. Considering that high sensitivity, selectivity, stability and a low limit of detection (LOD) are inevitable requirements for an ideal biosensor, the class of conducting polymers of poly(3,4-ethylenedioxythiophene) (PEDOT) and recently poly(3,4-propylenedioxythiophene) (PProDOT) materials have been demonstrated to be promising candidates for designing sensor devices. Nanostructure engineering of these polymeric materials with tunable surface properties and side chain functionalization to enable sensor probe conjugation combined with signal amplification devices such as OECTs and OFETs can fulfil the requirements of next-generation smart nano-biosensors. In this review, we analyze recent reports on PEDOT/PProDOT nanostructures and nanocomposites for developing nano-biosensors and their application in the detection of different biomarkers, environmental, toxicology, marine and aquatic monitoring, forensic and illicit drug detection, . In addition, we discuss the challenges associated with the design of PEDOT/PProDOT nano-biosensors and future perspectives on the exploration of novel sensor platforms, particularly PProDOT derivatives for bioelectronics and novel design strategies for next-generation smart nano-biosensors.