Department of Neurology, Baskent Unıversity, Hospital Konya, Selçuklu, Turkey.
Eur Rev Med Pharmacol Sci. 2024 Aug;28(16):4170-4178. doi: 10.26355/eurrev_202408_36669.
Greater occipital nerve (GON) blockade injections can be used to prevent episodic and chronic cluster headaches. In recent studies, prophylactic treatment has been used in addition to the GON blockade. In this study, we aimed to elucidate the effect of GON blockade on the attack frequency, pain intensity, and duration in patients diagnosed with chronic cluster headaches.
The demographic characteristics of 30 patients who received GON blockade along with acute attack treatment, short- and long-term prophylactic treatment for cluster headache, and 24 patients who received only acute attack treatment, short- and long-term prophylactic treatment, before blockade treatment, in the 1st week and 1st month after blockade were investigated. Attack frequency, attack duration, and visual analog scale (VAS) variables were compared.
We evaluated the VAS score, daily attack frequency, and duration of pain attacks after repeated GON blockade and found a statistically significant difference in the VAS score, daily attack frequency, duration of pain attacks, average values of the treatment, and time interaction of pain intensity in the group in which GON blockade was applied in the 1st week and 1st month compared to the pre-treatment period (p<0.01), (p<0.01), (p=0.044).
Regarding the outcomes of this research, GON blockade provided significant improvement in pain frequency, attack duration, and VAS score in the period from attack treatment to the start of long-term prophylaxis treatment and one month after treatment, without the need to switch to different prophylaxis treatments. Therefore, GON blockade may be a preferable and reliable treatment option.
枕大神经(GON)阻滞注射可用于预防阵发性和慢性丛集性头痛。在最近的研究中,预防性治疗已被用于 GON 阻滞之外。在这项研究中,我们旨在阐明 GON 阻滞对诊断为慢性丛集性头痛患者的发作频率、疼痛强度和持续时间的影响。
研究了 30 名患者的人口统计学特征,这些患者在接受 GON 阻滞以及急性发作治疗、丛集性头痛的短期和长期预防性治疗后,以及 24 名仅接受急性发作治疗、短期和长期预防性治疗的患者,在阻滞治疗前、阻滞治疗后第 1 周和第 1 个月。比较了发作频率、发作持续时间和视觉模拟量表(VAS)变量。
我们评估了重复 GON 阻滞后的 VAS 评分、每日发作频率和疼痛发作持续时间,发现与治疗前相比,GON 阻滞第 1 周和第 1 个月 VAS 评分、每日发作频率、疼痛发作持续时间、疼痛强度的平均值和治疗时间交互作用在组中有统计学显著差异(p<0.01),(p<0.01),(p=0.044)。
根据本研究的结果,GON 阻滞在从急性发作治疗到开始长期预防治疗以及治疗后一个月的时间内,显著改善了疼痛频率、发作持续时间和 VAS 评分,无需切换到不同的预防治疗。因此,GON 阻滞可能是一种更可取和可靠的治疗选择。