Department of Urology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
CAAC East China Aviation Personnel Medical Appraisal Center, Civil Aviation Shanghai Hospital, Shanghai, China.
Ren Fail. 2024 Dec;46(2):2390566. doi: 10.1080/0886022X.2024.2390566. Epub 2024 Sep 4.
To investigate the association between atherogenic index of plasma (AIP) and kidney stones (KS) occurrence and recurrence.
Data were obtained from the National Health and Nutrition Examination Survey (NHANES) 2007-2014. Non-pregnant adults who provided complete information on AIP and KS were included in the analyses. AIP was calculated as log (triglyceride/high-density lipoprotein cholesterol). KS was ascertained with questionnaires. Weighted multivariable logistic regression model and restricted cubic spline (RCS) were applied to examine the associations between AIP and KS occurrence and recurrence.
A total of 6488 subjects (weighted mean age 43.19 years and 49.26% male) with a weighted mean AIP of 0.66 were included in this study. The multivariable-adjusted OR for nephrolithiasis occurrence across consecutive tertiles was 1.00 (reference), 1.21 (95% CI: 0.90-1.62), and 1.85 (95% CI: 1.39-2.48), respectively. Moreover, each SD increment of AIP was associated with a 50% (OR:1.50, 95% CI: 1.25-1.81) higher risk of nephrolithiasis recurrence. RCSs showed significant and linear dose-response relationships between AIP and nephrolithiasis occurrence (-overall = 0.006, -nonlinear = 0.689) and recurrence (-overall = 0.001, -nonlinear = 0.848). The positive associations between AIP and nephrolithiasis occurrence and recurrence persisted in sensitivity analyses, suggesting the robustness of the results.
In the current US nationally representative cross-sectional study, AIP was positively associated with KS occurrence and recurrence.
探讨血浆致动脉粥样硬化指数（AIP）与肾结石（KS）发生和复发的关系。
数据来自 2007-2014 年全国健康与营养调查（NHANES）。分析纳入了提供完整 AIP 和 KS 信息的非妊娠成年人。AIP 计算为 log（甘油三酯/高密度脂蛋白胆固醇）。KS 通过问卷确定。应用加权多变量逻辑回归模型和限制三次样条（RCS）来检验 AIP 与 KS 发生和复发之间的关系。
本研究共纳入 6488 名受试者（加权平均年龄为 43.19 岁，男性占 49.26%），AIP 的加权平均值为 0.66。连续三分位的肾结石发生的多变量校正比值比分别为 1.00（参考）、1.21（95%CI：0.90-1.62）和 1.85（95%CI：1.39-2.48）。此外，AIP 每增加一个标准差，肾结石复发的风险就会增加 50%（OR：1.50，95%CI：1.25-1.81）。RCS 显示 AIP 与肾结石发生（-总体=0.006，-非线性=0.689）和复发（-总体=0.001，-非线性=0.848）之间存在显著的线性剂量-反应关系。敏感性分析表明，AIP 与肾结石发生和复发之间的正相关关系持续存在，这表明结果是稳健的。
在目前这项美国全国代表性的横断面研究中，AIP 与 KS 的发生和复发呈正相关。
