Department of Endocrinology, Affiliated Kunshan Hospital of Jiangsu University, Kunshan, Jiangsu, 215300, China.
BMC Urol. 2024 Aug 24;24(1):179. doi: 10.1186/s12894-024-01567-9.
The atherogenic index of plasma (AIP) is a novel comprehensive lipid index. We aimed to investigate a possible relationship between AIP index and kidney stones in US adults.
This cross-sectional study was conducted among adults with complete AIP index and questionnaire records on kidney stones from the National Health and Nutrition Examination Survey (NHANES) spanning from 2007 to 2018. The AIP index served as the exposure variable, defined as the logarithm of the ratio between triglycerides (TG, mmol/L) and high-density lipoprotein cholesterol (HDL-c, mmol/L). Self-reported history of kidney stones was utilized as the outcome variable. The independent relationship between AIP index and the risk of kidney stones was fully assessed.
A total of 14,833 participants were included in this study, with an average AIP index of -0.07 ± 0.01. The proportion of kidney stones progressively increased with higher AIP index tertile intervals (7.33% vs. 9.97% vs. 12.57%, P < 0.001). Furthermore, AIP index was found to be independently associated with the risk of kidney stones after adjusting for confounding factors (OR = 1.32, 95% CI 1.08-1.61, P = 0.006). Restricted cubic spline (RCS) analysis confirmed the robustness of our results. There was no significant interaction observed based on subgroup analysis stratified by age, gender, race, body mass index (BMI, kg/m), smokers, diabetes, hypertension, and cardiovascular disease (P for interaction > 0.05).
The AIP index may be a potential epidemiological tool to quantify the role of dyslipidemia in the risk of kidney stones in US adults.
血浆致动脉粥样硬化指数（AIP）是一种新的综合脂质指数。我们旨在研究美国成年人中 AIP 指数与肾结石之间可能存在的关系。
本横断面研究纳入了美国国家健康与营养调查（NHANES）中 2007 年至 2018 年期间具有完整 AIP 指数和肾结石问卷记录的成年人。AIP 指数作为暴露变量，定义为甘油三酯（TG，mmol/L）与高密度脂蛋白胆固醇（HDL-c，mmol/L）的比值的对数。肾结石的自述史用作结局变量。充分评估了 AIP 指数与肾结石风险之间的独立关系。
本研究共纳入 14833 名参与者，平均 AIP 指数为-0.07±0.01。肾结石的比例随 AIP 指数三分位间隔的升高而逐渐增加（7.33%比 9.97%比 12.57%，P<0.001）。此外，在调整混杂因素后，AIP 指数与肾结石的风险独立相关（OR=1.32，95%CI 1.08-1.61，P=0.006）。受限立方样条（RCS）分析证实了我们结果的稳健性。根据年龄、性别、种族、体重指数（BMI，kg/m）、吸烟者、糖尿病、高血压和心血管疾病等亚组分析，未观察到显著的交互作用（P 交互>0.05）。
AIP 指数可能是一种潜在的流行病学工具，可以量化血脂异常在美国成年人肾结石风险中的作用。
