Namık Kemal University, Faculty of Medicine, Department of Cardiology - Tekirdağ, Turkey.
Rev Assoc Med Bras (1992). 2024 Sep 2;70(8):e20240515. doi: 10.1590/1806-9282.20240515. eCollection 2024.
Coronary artery disease (CAD) is frequent, but coronary slow flow (CSF) is a less common cardiovascular disease with a significant risk of mortality and morbidity. Endocan is a proinflammatory glycopeptide that has been investigated in cardiovascular diseases as well as some inflammatory diseases in recent years. We planned to compare the levels of endocan in both CAD and CSF in a similar population and examine the relationship of endocan with additional clinical variables.
In the trial, we included 169 consecutive subjects having a coronary angiography indication. According to the results of coronary angiography, 58 people were included in the CAD group, 52 were in the CSF group, and 59 people were in the control group. The control group includes those who did not have any lesions in their epicardial coronary arteries. Thrombolysis in myocardial infarction (TIMI)-frame counts (TFC) were calculated for all patients.
Notably, 2.6% of the population in our study had CSF. Both the CAD (555±223 pg/mL) and CSF (559±234 pg/mL) groups had higher endocan levels than the control group (331±252 pg/mL) (p<0.001). There were similar endocan levels between the CAD and CSF groups. Endocan levels were shown to be favorably associated with mean TFC (r=0.267; p0.001). Serum endocan levels (particularly those above 450 pg/mL) and the presence of hyperlipidemia were the most important predictors of both CAD and CSF.
Endocan levels are higher in CAD and CSF patients than in those with normal coronary arteries.
冠心病（CAD）较为常见，但冠状动脉慢血流（CSF）是一种较少见的心血管疾病，具有较高的死亡率和发病率。内皮细胞特异性分子-1（Endocan）是一种促炎糖肽，近年来已在心血管疾病以及一些炎症性疾病中进行了研究。我们计划在相似人群中比较 CAD 和 CSF 中 Endocan 的水平，并研究 Endocan 与其他临床变量的关系。
在该试验中，我们纳入了 169 例连续进行冠状动脉造影的患者。根据冠状动脉造影结果，将 58 例患者纳入 CAD 组，52 例患者纳入 CSF 组，59 例患者纳入对照组。对照组指那些心外膜冠状动脉无任何病变的患者。为所有患者计算心肌梗死溶栓治疗（TIMI）帧数计数（TFC）。
值得注意的是，我们研究人群中 CSF 的发生率为 2.6%。CAD 组（555±223 pg/mL）和 CSF 组（559±234 pg/mL）的 Endocan 水平均高于对照组（331±252 pg/mL）（p<0.001）。CAD 组和 CSF 组的 Endocan 水平相似。Endocan 水平与平均 TFC 呈正相关（r=0.267；p<0.001）。血清 Endocan 水平（特别是高于 450 pg/mL）和高脂血症的存在是 CAD 和 CSF 的最重要预测因素。
CAD 和 CSF 患者的 Endocan 水平高于正常冠状动脉患者。
