Department of Applied Chemistry, Graduate School of Engineering, Osaka Prefecture University, 1-1, Gakuen-cho, Naka-ku, Sakai, Osaka 599-8531, Japan.
Department of Applied Chemistry, Graduate School of Engineering, Osaka Metropolitan University, 1-1, Gakuen-cho, Naka-ku, Sakai, Osaka 599-8531, Japan.
Biomacromolecules. 2024 Oct 14;25(10):6465-6473. doi: 10.1021/acs.biomac.4c00605. Epub 2024 Sep 4.
The functionalization approach for nanomaterials is of great importance for their application in drug delivery systems. Herein, an approach based on block copolymer installation into polymer nanogels was newly developed. Poly(vinyl alcohol)-incorporated polymer nanogels were prepared by a two-step dispersion/precipitation polymerization. Poly(methacrylic acid)--poly(3-fluorophenylboronic acid methacrylamide) (PMAA--PFPBMA) prepared by two-step reversible addition-fragmentation chain transfer polymerization was installed into the polymer nanogels via boronate ester formation. Furthermore, cisplatin as a cancer therapeutic drug was successfully loaded on the block copolymer-installed polymer nanogels, and cell death was achieved by using the resulting cisplatin-loaded nanogels. We believe that the functionality of the nanogels can be changed by varying the installed block copolymer, leading to the functionalization approach of polymer nanogels based on block copolymer installation, which will be of great utility in many fields.
纳米材料的功能化方法对于其在药物传递系统中的应用非常重要。在此，新开发了一种基于将嵌段共聚物安装到聚合物纳米凝胶中的方法。通过两步分散/沉淀聚合制备了包含聚乙烯醇的聚合物纳米凝胶。通过两步可逆加成-断裂链转移聚合制备的聚（甲基丙烯酸）-聚（3-氟苯硼酸甲基丙烯酰胺）（PMAA-PFPBMA）通过硼酸酯形成被安装到聚合物纳米凝胶中。此外，顺铂作为癌症治疗药物成功地负载在嵌段共聚物安装的聚合物纳米凝胶上，并且通过使用所得的负载顺铂的纳米凝胶实现了细胞死亡。我们相信，通过改变安装的嵌段共聚物可以改变纳米凝胶的功能，从而实现基于嵌段共聚物安装的聚合物纳米凝胶的功能化方法，这将在许多领域非常有用。
