Xia Teng, Yuan Qian, Xing Shi-Gui
Department of Thoracic Surgery, Nan Jing Gaochun People's Hospital, The Gaochun Affiliated Hospital of Jiang Su University), Nanjing, 210000, Jiangsu, China.
Clin Transl Oncol. 2025 Apr;27(4):1345-1355. doi: 10.1007/s12094-024-03681-4. Epub 2024 Sep 4.
Spread through air spaces (STAS) represents a relatively novel concept in the pathology of lung cancer, and it specifically refers to the dissemination of tumour cells into the parenchymal air spaces adjacent to the primary tumour. In 2015, the World Health Organization (WHO) classified STAS as a new invasive form of lung adenocarcinoma (LUAD). Many studies investigated the role of STAS and revealed its association with the prognosis of LUAD and its influence on the outcomes of other malignant pulmonary neoplasms. Additionally, the underlying mechanisms and predictive models of STAS have received considerable attention in recent years. This paper provides a comprehensive overview of the research advancements and prospects of STAS by examining it from multiple perspectives.
气腔播散（STAS）在肺癌病理学中是一个相对较新的概念，它具体指肿瘤细胞扩散到原发肿瘤附近的实质气腔中。2015年，世界卫生组织（WHO）将STAS归类为肺腺癌（LUAD）的一种新的侵袭形式。许多研究调查了STAS的作用，并揭示了它与LUAD预后的关联及其对其他恶性肺肿瘤结局的影响。此外，近年来STAS的潜在机制和预测模型受到了相当多的关注。本文从多个角度审视STAS，对其研究进展和前景进行全面概述。
