J Drugs Dermatol. 2024 Sep 1;23(9):725-728. doi: 10.36849/JDD.8029.
Minoxidil is an anti-hypertensive vasodilator increasingly used off-label for the treatment of alopecia. It is associated with an increased risk of pericardial effusions, with recent reports even in patients on low-dose oral minoxidil (LDOM) therapy.
To evaluate whether LDOM is associated with increased prevalence of pericardial effusions in patients with alopecia.
In this cross-sectional study, point-of-care ultrasound was used to screen alopecia patients at dermatology appointments. Scans were evaluated by two independent cardiologists for the presence and size of effusions. The prevalence of effusions was compared between patients on LDOM therapy and patients not on minoxidil therapy.
A total of 100 patients were evaluated for pericardial effusion: 51 LDOM patients and 49 control patients. The two groups were similar in terms of age (53.7 vs 54.1; P=0.91), sex (86% vs 73% female; P=0.14), and race. Small pericardial effusions (<1 cm) were identified in 5.8% of LDOM patients and 6% of control patients (P=1), none of which were symptomatic.
This is a small, cross-sectional study with limitations on speculation of causality in confirmed cases.
We did not find evidence of increased prevalence of pericardial effusions in a small group of alopecia patients on LDOM. J Drugs Dermatol. 2024;23(9):725-728. doi:10.36849/JDD.8029.
米诺地尔是一种抗高血压血管扩张剂，越来越多地被超适应证用于治疗脱发。它与心包积液的风险增加有关，最近甚至有报道称低剂量口服米诺地尔（LDOM）治疗的患者也会出现这种情况。
评估 LDOM 是否与脱发患者心包积液的患病率增加有关。
在这项横断面研究中，我们在皮肤科就诊时使用即时超声来筛查脱发患者。两名独立的心脏病专家对积液的存在和大小进行了扫描评估。比较了 LDOM 治疗患者和未接受米诺地尔治疗患者的心包积液患病率。
共有 100 名患者接受了心包积液评估：51 名 LDOM 患者和 49 名对照患者。两组在年龄（53.7 岁 vs 54.1 岁；P=0.91）、性别（86% vs 73%女性；P=0.14）和种族方面相似。5.8%的 LDOM 患者和 6%的对照组患者存在小量心包积液（<1 cm）（P=1），均无明显症状。
这是一项小型的横断面研究，在确诊病例中存在因果关系推测的局限性。
我们没有在一组接受 LDOM 的脱发小患者中发现心包积液患病率增加的证据。皮肤病药物杂志。2024；23（9）：725-728。doi：10.36849/JDD.8029.
