低剂量口服米诺地尔在高血压和心律失常患者中的安全性：一项对264例患者的多中心研究。

Safety of Low-Dose Oral Minoxidil in Patients With Hypertension and Arrhythmia: A Multicenter Study of 264 Patients.

作者信息

Jimenez-Cauhe J, Pirmez R, Müller-Ramos P, Melo D F, Ortega-Quijano D, Moreno-Arrones O M, Saceda-Corralo D, Gil-Redondo R, Hermosa-Gelbard A, Dias-Sanabria B, Restom D, Porriño-Bustamante M L, Pindado-Ortega C, Berna-Rico E, Fernandez-Nieto D, Ramos M, Jaen-Olasolo P, Vaño-Galvan S

机构信息

Dermatology Department, Hospital Universitario Ramon y Cajal, IRYCIS, Universidad de Alcala, Spain; Trichology Unit, Grupo de Dermatologia Pedro Jaen, Madrid, Spain.

Instituto de Dermatologia Professor Rubem David Azulay, Santa Casa de Misericórdia do Rio de Janeiro, Rio de Janeiro, Brazil.

出版信息

Actas Dermosifiliogr. 2024 Jan;115(1):28-35. doi: 10.1016/j.ad.2023.07.019. Epub 2023 Aug 29.

DOI:10.1016/j.ad.2023.07.019

PMID:37652097

Abstract

BACKGROUND AND OBJECTIVE

Systemic adverse effects (AE) are a major concern of low-dose oral minoxidil (LDOM) treatment, especially in patients with arterial hypertension or arrhythmia. The objective of this study was to evaluate the safety of LDOM in patients with hypertension or arrhythmia.

PATIENTS AND METHODS

Retrospective multicenter study of patients with hypertension or arrhythmia treated with LDOM for any type of alopecia.

RESULTS

A total of 254 patients with hypertension [176 women (69.3%) and 78 men (30.7%)] with a mean age of 56.9 years (range 19-82) were included. From them, the dose of LDOM was titrated in 128 patients, allowing the analysis of 382 doses. Patients were receiving a mean of 1.45 (range 0-5) antihypertensive drugs. Systemic AE were detected in 26 cases (6.8%) and included lightheadedness (3.1%), fluid retention (2.6%), general malaise (0.8%), tachycardia (0.8%) and headache (0.5%), leading to LDOM discontinuation in 6 cases (1.5%). Prior treatment with doxazosin (P<0.001), or with three or more antihypertensive drugs (P=0.012) was associated with a higher risk of discontinuation of LDOM.

CONCLUSIONS

LDOM treatment showed a favorable safety profile in patients with hypertension or arrhythmia, similar to general population.

摘要

背景与目的

全身不良反应是小剂量口服米诺地尔（LDOM）治疗的主要关注点，尤其是在患有动脉高血压或心律失常的患者中。本研究的目的是评估LDOM在高血压或心律失常患者中的安全性。

患者与方法

对因任何类型脱发而接受LDOM治疗的高血压或心律失常患者进行回顾性多中心研究。

结果

共纳入254例高血压患者[176例女性（69.3%）和78例男性（30.7%）]，平均年龄56.9岁（范围19 - 82岁）。其中，128例患者的LDOM剂量进行了滴定，共分析382剂。患者平均正在服用1.45种（范围0 - 5种）抗高血压药物。检测到26例（6.8%）全身不良反应，包括头晕（3.1%）、液体潴留（2.6%）、全身不适（0.8%）、心动过速（0.8%）和头痛（0.5%），导致6例（1.5%）患者停用LDOM。先前使用多沙唑嗪治疗（P<0.001）或使用三种或更多抗高血压药物（P = 0.012）与停用LDOM的较高风险相关。