新型抗惊厥药登齐莫尔与卡马西平和苯妥英的相互作用。
The interaction of denzimol (a new anticonvulsant) with carbamazepine and phenytoin.
作者信息
Patsalos P N, Shorvon S D, Elyas A A, Smith G
出版信息
J Neurol Neurosurg Psychiatry. 1985 Apr;48(4):374-7. doi: 10.1136/jnnp.48.4.374.
Abstract
Denzimol, a new anticonvulsant drug, is currently undergoing clinical evaluation. In this paper we report its use in six patients who were also taking carbamazepine and two patients taking phenytoin. There was a striking elevation of serum carbamazepine, carbamazepine-10, 11 epoxide and phenytoin concentrations in all patients on the addition of denzimol therapy. The interaction with carbamazepine is greater in severity than any other reported to date and denzimol's interaction with both carbamazepine and phenytoin is likely to prove of major clinical significance.
摘要
新型抗惊厥药物登齐莫尔目前正在进行临床评估。在本文中，我们报告了其在6名同时服用卡马西平的患者和2名服用苯妥英钠的患者中的应用情况。在所有患者中，添加登齐莫尔治疗后，血清卡马西平、卡马西平-10,11-环氧化物和苯妥英钠浓度均显著升高。登齐莫尔与卡马西平的相互作用比迄今为止报道的任何相互作用都更为严重，而且登齐莫尔与卡马西平和苯妥英钠的相互作用可能具有重大临床意义。
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