Department of Ophthalmology (Y.C.Y., S.C.H.), Basaksehir Cam Sakura State Hospital, Istanbul, Turkey; Department of Ophthalmology (Y.C.Y., S.C.I.), Agri Ibrahim Cecen University Faculty of Medicine, Agri, Turkey; and Bodrum Gozakademi Private Eye Hospital (S.C.I.), Bodrum, Mugla, Turkey.
Eye Contact Lens. 2024 Nov 1;50(11):482-488. doi: 10.1097/ICL.0000000000001126. Epub 2024 Sep 4.
The aim of the study was to investigate the corneal and anterior segment characteristics in pseudoexfoliation syndrome (PXS), depending on the severity of the disease.
This cross-sectional study was conducted at a tertiary care hospital, in the ophthalmology department, in Turkey. Pseudoexfoliation syndrome group was classified into three groups. Pseudoexfoliative material on the part of the pupillary border was classified as group 1, on the entire pupillary border was classified as group 2, and pseudoexfoliative material on the entire pupillary border and iris surface was classified as group 3. The control group was composed of age and gender-matched individuals who had undergone a completely normal ophthalmologic examination. Scheimpflug tomography was performed to record tomographical data.
The PXS groups 1, 2, and 3, along with the control group, consist of 29, 32, 33, and 42 participants, respectively. There was no significant difference in age-gender distribution between patients and the control group ( P >0.05). Group 3 showed significant differences in central corneal thickness compared with the control group ( P =0.001). In addition, anterior chamber angle was found to be significantly lower in group 3 than the control group ( P <0.001). In corneal densitometry (CD) values, significant increases compared with the control group were observed in groups 2 and 3 across all anterior annuli ( P <0.001). In group 1, significant increases observed in the anterior 6-10 mm and 10-12 mm annuli ( P <0.001). In the middle 6-10 mm annuluses, only group 3 showed a significant increase compared with the control group ( P <0.001). In the posterior 0-2, 2-6, and 6-10 mm annuli, significant increases compared with the control were observed only in groups 2 and 3 ( P =0.001, P =0.001, P <0.001, respectively).
Corneal densitometry values, even without an increase in intraocular pressure, have a tendency to increase in PXS depending on the severity of the disease. While minimal changes were observed in the middle layer, it was particularly noted that the effects of the disease were more prominent in the peripheral cornea.
本研究旨在探讨假性剥脱综合征（PXS）患者的角膜和眼前节特征与疾病严重程度的关系。
这是一项在土耳其一家三级医院眼科进行的横断面研究。将 PXS 患者分为 3 组：瞳孔缘有假性剥脱物质的为 1 组，整个瞳孔缘有假性剥脱物质的为 2 组，整个瞳孔缘和虹膜表面有假性剥脱物质的为 3 组。对照组由年龄和性别匹配、接受过完全正常眼科检查的个体组成。采用 Scheimpflug 断层摄影术记录断层数据。
PXS 组 1、2、3 及对照组分别包含 29、32、33 和 42 名参与者。患者与对照组在年龄和性别分布上无显著差异（P>0.05）。与对照组相比，组 3 的中央角膜厚度有显著差异（P=0.001）。此外，组 3 的前房角较对照组明显降低（P<0.001）。在角膜密度（CD）值方面，与对照组相比，组 2 和 3 在前部所有环中均有显著升高（P<0.001）。在组 1 中，前 6-10mm 和 10-12mm 环有显著升高（P<0.001）。在中 6-10mm 环中，只有组 3 与对照组相比有显著升高（P<0.001）。在后部 0-2、2-6 和 6-10mm 环中，仅组 2 和 3 与对照组相比有显著升高（P=0.001、P=0.001、P<0.001）。
即使眼压没有升高，PXS 患者的角膜密度值也会随着疾病的严重程度而升高。虽然中间层的变化很小，但值得注意的是，疾病对周边角膜的影响更为明显。
