Randolph M F, Gerber M A, DeMeo K K, Wright L
J Pediatr. 1985 Jun;106(6):870-5. doi: 10.1016/s0022-3476(85)80228-6.
We examined the effect of antibiotic therapy on the clinical course of group A beta-hemolytic streptococcal (GABHS) pharyngitis in 260 children. After a throat culture had been obtained, each child was evaluated for the presence of predetermined signs and symptoms, and was then randomized in a double-blind manner to receive penicillin V, cefadroxil, or placebo. Of the 194 children with throat cultures positive for GABHS, 68 received penicillin V, 70 received cefadroxil, and 56 received placebo. Approximately 18 to 24 hours later, each patient returned for reevaluation. Significantly fewer children who had received either penicillin or cefadroxil had persistence of each of the three objective signs and each of the three subjective symptoms than did children who had received placebo. In addition, the evaluating physician, parents, and patients all believed that significantly fewer of the patients given antibiotic failed to demonstrate overall clinical improvement.
我们研究了抗生素治疗对260名儿童A组β溶血性链球菌（GABHS）咽炎临床病程的影响。在获取咽拭子培养结果后，对每个儿童进行评估，以确定是否存在预先设定的体征和症状，然后以双盲方式随机分配接受青霉素V、头孢羟氨苄或安慰剂治疗。在194名咽拭子培养结果为GABHS阳性的儿童中，68名接受青霉素V治疗，70名接受头孢羟氨苄治疗，56名接受安慰剂治疗。大约18至24小时后，每位患者返回进行重新评估。与接受安慰剂治疗的儿童相比，接受青霉素或头孢羟氨苄治疗的儿童出现三种客观体征和三种主观症状中的任何一种持续存在的情况明显更少。此外，评估医生、家长和患者都认为，接受抗生素治疗的患者中未能显示出总体临床改善的人数明显更少。
