Gerber M A
Drugs. 1986;32 Suppl 3:29-32. doi: 10.2165/00003495-198600323-00006.
The efficacy of cefadroxil, an orally administered broad spectrum cephalosporin, was compared with that of penicillin V in several studies comprising more than 550 children with group A beta-haemolytic streptococcal (GABHS) pharyngitis. Both drugs alleviated clinical signs and symptoms and eradicated GABHS from the upper respiratory tract within 18 to 24 hours of the initiation of therapy. Approximately 8% of the patients treated with either cefadroxil or penicillin V had strains of GABHS isolated from 1 of their follow-up throat cultures which were identical to the strains isolated from their initial throat cultures, and were considered bacteriological treatment failures. Compliance was greater than 90% with all of the regimens used, but was significantly better with cefadroxil given as a 30 mg/kg dose once daily than with penicillin V given 3 times daily. There were no serious adverse reactions with either drug. Thus, cefadroxil was shown to be well tolerated and as effective as the standard agent, oral penicillin V, in the treatment of GABHS pharyngitis in children.
在几项针对550多名患有A组β溶血性链球菌（GABHS）咽炎儿童的研究中，对口服广谱头孢菌素头孢羟氨苄与青霉素V的疗效进行了比较。两种药物均能缓解临床体征和症状，并在治疗开始后的18至24小时内清除上呼吸道中的GABHS。接受头孢羟氨苄或青霉素V治疗的患者中，约8%的患者在后续的一次咽喉培养中分离出的GABHS菌株与初始咽喉培养中分离出的菌株相同，这些患者被视为细菌学治疗失败。所有使用的治疗方案的依从性均超过90%，但每日一次给予30mg/kg剂量的头孢羟氨苄的依从性明显优于每日三次给予青霉素V的依从性。两种药物均未出现严重不良反应。因此，在治疗儿童GABHS咽炎方面，头孢羟氨苄耐受性良好，与标准药物口服青霉素V效果相当。
