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临床法医案件中物质使用情况的检测:受害者与犯罪者的尿液分析

Detection of substance use in clinical forensic cases: urine analysis of victims and perpetrators.

作者信息

Heinsvig Pia Johansson, Holler Katinka Rønnow, Lindholst Christian, Nielsen Trine Skov

机构信息

Department of Forensic Medicine, Section for Forensic Pathology, Aarhus University, Palle Juul-Jensens Boulevard 99, Aarhus N, 8200, Denmark.

出版信息

Forensic Sci Med Pathol. 2024 Sep 5. doi: 10.1007/s12024-024-00873-w.

Abstract

This study investigates the prevalence of substance use among victims and perpetrators involved in clinical forensic cases. Urine samples from 455 individuals aged 18 and above, collected in 2019, were analyzed using two LC-MS-based analytical methods and an HS-GC-FID method for the most frequently reported substances of abuse and medication. Data from case documents, encompassing gender, age, and the individual's role, were recorded in a database. Both the urine samples and the information from case documents were fully anonymized. The most frequently detected substance was alcohol (37% of all cases), followed by cannabis (22% of all cases) and central nervous system stimulants (24% of all cases). Other classes of substances detected included benzodiazepines, anabolic steroids, antipsychotic agents, and antidepressants. No drugs or alcohol were detected in 32% of the victims and 19% of the perpetrators. The study also examines the interrelationship of drug patterns between victims and perpetrators, and results show that both parties were influenced by substances at the time of the incident. Furthermore, there was a significant difference in the use of substances between perpetrators of blunt and sharp force cases and perpetrators in cases of sexual assault. Timely sample collection and a structured toxicological analysis of both victims and perpetrators in the same case are vital in clinical forensic cases to enhance comprehension of the connection between criminal activities and substance use. This understanding enables the development of prevention strategies at an informed level.

摘要

本研究调查了临床法医案件中的受害者和犯罪者的药物使用情况。对2019年收集的455名18岁及以上个体的尿液样本,使用两种基于液相色谱-质谱联用的分析方法和一种顶空-气相色谱-氢火焰离子化检测法,对最常报告的滥用药物和药物进行了分析。来自病例文件的数据,包括性别、年龄和个人角色,被记录在一个数据库中。尿液样本和病例文件中的信息都进行了完全匿名处理。最常检测到的物质是酒精(占所有病例的37%),其次是大麻(占所有病例的22%)和中枢神经系统兴奋剂(占所有病例的24%)。检测到的其他类物质包括苯二氮䓬类、合成代谢类固醇、抗精神病药物和抗抑郁药物。32%的受害者和19%的犯罪者未检测到药物或酒精。该研究还考察了受害者和犯罪者之间药物使用模式的相互关系,结果表明双方在事件发生时都受到了药物的影响。此外,钝器伤和锐器伤案件的犯罪者与性侵犯案件的犯罪者在药物使用方面存在显著差异。在临床法医案件中,及时采集同一案件中受害者和犯罪者的样本并进行结构化毒理学分析,对于增强对犯罪活动与药物使用之间联系的理解至关重要。这种理解有助于制定有充分依据的预防策略。

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