通过抑制炎症来对抗“IL-11 疾病”：健康长寿的策略。

Defying "IL-11ness" by inhibiting inflammation: Strategy for health and longevity.

机构信息

Department of Pathology, Yale School of Medicine, New Haven, CT 06520, USA; Department of Immunobiology and Comparative Medicine, Yale School of Medicine, New Haven, CT 06520, USA.

Department of Pathology, Yale School of Medicine, New Haven, CT 06520, USA; Department of Immunobiology and Comparative Medicine, Yale School of Medicine, New Haven, CT 06520, USA; Yale Center for Research on Aging, New Haven, CT 06520, USA.

出版信息

Cell Metab. 2024 Sep 3;36(9):1911-1913. doi: 10.1016/j.cmet.2024.08.003.

DOI:10.1016/j.cmet.2024.08.003

PMID:39232279

Abstract

Organismal aging involves several hallmark pathways, including chronic inflammation and metabolic dysfunction. However, the origin of age-related inflammation is incompletely understood. In a recent study published in Nature, Widjaja et al. show that blocking the age-related increase in IL-11 restores immune-metabolic homeostasis and extends healthspan and lifespan in mice.

摘要

生物体的衰老涉及几种标志性途径，包括慢性炎症和代谢功能障碍。然而，与年龄相关的炎症的起源尚不完全清楚。在最近发表在《自然》杂志上的一项研究中，Widjaja 等人表明，阻断与年龄相关的 IL-11 增加可恢复免疫代谢稳态，并延长小鼠的健康寿命和寿命。