Lee Erickson Jessica, Schuster Mariana
Leibniz Institute of Plant Biochemistry, Weinberg 3, 06120, Halle, Germany.
Curr Opin Plant Biol. 2024 Dec;82:102621. doi: 10.1016/j.pbi.2024.102621. Epub 2024 Sep 3.
Plant pathogens deploy specialized proteins to aid disease progression, some of these proteins function in the apoplast and constitute proteases. Extracellular virulence proteases have been described to play roles in plant cell wall manipulation and immune evasion. In this review, we discuss the evidence for the hypothesized virulence functions of bacterial, fungal, and oomycete extracellular proteases. We highlight the contrast between the low number of elucidated functions for these proteins and the size of extracellular protease repertoires among pathogens. Finally, we suggest that the refinement of in planta 'omics' approaches, combined with recent advances in modeling and mechanism-based methods for trapping substrates finally make it possible to address this knowledge gap.
植物病原体利用特殊蛋白质来促进疾病发展，其中一些蛋白质在质外体中发挥作用并构成蛋白酶。细胞外毒力蛋白酶已被描述在植物细胞壁操纵和免疫逃避中发挥作用。在本综述中，我们讨论了细菌、真菌和卵菌细胞外蛋白酶假定毒力功能的证据。我们强调了这些蛋白质已阐明功能数量较少与病原体中细胞外蛋白酶库规模之间的差异。最后，我们认为，植物体内“组学”方法的完善，结合建模和基于机制的底物捕获方法的最新进展，最终使得弥补这一知识差距成为可能。
