植物病原菌效应子颠覆宿主免疫：不同的敌人，相似的战场。

Phytopathogen effectors subverting host immunity: different foes, similar battleground.

机构信息

College of Plant Protection, Nanjing Agricultural University, Nanjing, 210095, China.

出版信息

Cell Host Microbe. 2012 Oct 18;12(4):484-95. doi: 10.1016/j.chom.2012.09.003.

DOI:10.1016/j.chom.2012.09.003

Abstract

Phytopathogenic bacteria, fungi, and oomycetes invade and colonize their host plants through distinct routes. These pathogens secrete diverse groups of effector proteins that aid infection and establishment of different parasitic lifestyles. Despite this diversity, a comparison of different plant-pathogen systems has revealed remarkable similarities in the host immune pathways targeted by effectors from distinct pathogen groups. Immune signaling pathways mediated by pattern recognition receptors, phytohormone homeostasis or signaling, defenses associated with host secretory pathways and pathogen penetrations, and plant cell death represent some of the key processes controlling disease resistance against diverse pathogens. These immune pathways are targeted by effectors that carry a wide range of biochemical functions and are secreted by completely different pathogen groups, suggesting that these pathways are a common battleground encountered by many plant pathogens.

摘要

植物病原细菌、真菌和卵菌通过不同途径入侵和定殖宿主植物。这些病原体分泌多种效应蛋白，以帮助感染和建立不同的寄生生活方式。尽管存在这种多样性，但对不同植物-病原体系统的比较表明，不同病原体群体的效应子靶向的宿主免疫途径具有显著的相似性。由模式识别受体介导的免疫信号通路、植物激素稳态或信号通路、与宿主分泌途径和病原体穿透相关的防御、以及植物细胞死亡，代表了控制对多种病原体抗性的一些关键过程。这些免疫途径是效应子的靶标，效应子携带广泛的生化功能，并由完全不同的病原体群体分泌，这表明这些途径是许多植物病原体共同遇到的一个常见战场。