Zhou Shiran, Tu Zubo, Chen Zhigang, Jiang Dong, Lv Shujun, Cui Haidong
Department of Orthopedics, Haian People's Hospital, No. 17 Zhongba Middle Road, Haian City, Jiangsu Province 226600, China.
Department of Orthopedics, Haian People's Hospital, No. 17 Zhongba Middle Road, Haian City, Jiangsu Province 226600, China.
Colloids Surf B Biointerfaces. 2025 Jan;245:114189. doi: 10.1016/j.colsurfb.2024.114189. Epub 2024 Aug 29.
With the increasing aging population, the demand for orthopedic implants is also growing. Polyether ether ketone (PEEK) is considered a promising material for orthopedic implants due to its excellent biocompatibility. However, the lack of bioactivity and excessive immune response post-implantation often impair bone integration. Therefore, it is urgent to bio-functionalize PEEK-based implants to promote bone integration. This study employs a simple, economical, and feasible method to coat Ga-ion doped bioactive glass nanoparticles (Ga-MBGs) onto sulfonated PEEK surfaces, constructing a multifunctional PEEK-based orthopedic implant. The resulting bio-functionalized PEEK implants promote macrophage M2 phenotype polarization, thus fostering an anti-inflammatory immune microenvironment. Moreover, the direct osteogenic effect of Ga ions and the immuno-osteogenic effect through promoting macrophage M2 polarization enhance osteogenic differentiation potential in vitro and bone integration in vivo. A sequence of in vivo and in vitro experiments substantiates the essential and intricate function of this innovative orthopedic implants. in regulating normal bone immunity and metabolism. Overall, the application of Ga-MBGs provides a simple, economical, and effective method for developing multifunctional orthopedic implants. This surface bio-functionalized PEEK implant, capable of modulating immunity and bone metabolism, holds significant clinical application potential as an orthopedic implant.
随着人口老龄化的加剧，对骨科植入物的需求也在不断增长。聚醚醚酮（PEEK）因其优异的生物相容性而被认为是一种有前景的骨科植入物材料。然而，植入后缺乏生物活性和过度的免疫反应常常会损害骨整合。因此，迫切需要对基于PEEK的植入物进行生物功能化处理以促进骨整合。本研究采用一种简单、经济且可行的方法，将镓离子掺杂的生物活性玻璃纳米颗粒（Ga-MBGs）涂覆在磺化PEEK表面，构建一种多功能的基于PEEK的骨科植入物。所得的生物功能化PEEK植入物促进巨噬细胞M2表型极化，从而营造一个抗炎免疫微环境。此外，镓离子的直接成骨作用以及通过促进巨噬细胞M2极化的免疫成骨作用增强了体外成骨分化潜能和体内骨整合。一系列体内和体外实验证实了这种创新型骨科植入物在调节正常骨免疫和代谢方面的重要且复杂的功能。总体而言，Ga-MBGs的应用为开发多功能骨科植入物提供了一种简单、经济且有效的方法。这种能够调节免疫和骨代谢的表面生物功能化PEEK植入物作为骨科植入物具有显著的临床应用潜力。
