Guangdong Medical University, Zhanjiang, China.
The Spine Department, Orthopaedic Center, Guangdong Second Provincial General Hospital, Zhanjiang, China.
J Biomed Mater Res A. 2024 Sep;112(9):1565-1577. doi: 10.1002/jbm.a.37710. Epub 2024 Mar 21.
Polyether ether ketone (PEEK) is gaining recognition as a highly promising polymer for orthopedic implants, attributed to its exceptional biocompatibility, ease of processing, and radiation resistance. However, its long-term in vivo application faces challenges, primarily due to suboptimal osseointegration from postimplantation inflammation and immune reactions. Consequently, biofunctionalization of PEEK implant surfaces emerges as a strategic approach to enhance osseointegration and increase the overall success rates of these implants. In our research, we engineered a multifaceted PEEK implant through the in situ integration of chitosan-coated zinc-doped bioactive glass nanoparticles (Zn-BGNs). This novel fabrication imbues the implant with immunomodulatory capabilities while bolstering its osseointegration potential. The biofunctionalized PEEK composite elicited several advantageous responses; it facilitated M2 macrophage polarization, curtailed the production of inflammatory mediators, and augmented the osteogenic differentiation of bone marrow mesenchymal stem cells. The experimental findings underscore the vital and intricate role of biofunctionalized PEEK implants in preserving normal bone immunity and metabolism. This study posits that utilizing chitosan-BGNs represents a direct and effective method for creating multifunctional implants. These implants are designed to facilitate biomineralization and immunomodulation, making them especially apt for orthopedic applications.
聚醚醚酮（PEEK）作为一种极具应用前景的骨科植入物聚合物，由于其出色的生物相容性、易于加工和抗辐射性而备受关注。然而，其在体内的长期应用面临挑战，主要是由于植入后炎症和免疫反应导致的骨整合效果不佳。因此，对 PEEK 植入物表面进行生物功能化是一种增强骨整合、提高这些植入物整体成功率的策略方法。在我们的研究中，我们通过原位整合壳聚糖包覆的锌掺杂生物活性玻璃纳米颗粒（Zn-BGNs）对多方面的 PEEK 植入物进行了工程设计。这种新颖的制造方法赋予了植入物免疫调节能力，同时增强了其骨整合潜力。生物功能化的 PEEK 复合材料引发了多种有利的反应；它促进了 M2 巨噬细胞的极化，减少了炎症介质的产生，并增强了骨髓间充质干细胞的成骨分化。实验结果强调了生物功能化 PEEK 植入物在维持正常骨免疫和代谢方面的重要和复杂作用。本研究提出，利用壳聚糖-BGNs 是制造多功能植入物的一种直接有效的方法。这些植入物旨在促进生物矿化和免疫调节，特别适合骨科应用。
