Jiang Xinyue, Wang Hongzhan, Nie Kexin, Gao Yang, Chen Shen, Tang Yueheng, Wang Zhi, Su Hao, Dong Hui
Institute of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Department of Rehabilitation Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Chin Med. 2024 Sep 4;19(1):120. doi: 10.1186/s13020-024-00988-w.
Lipid droplet (LD) is a metabolically active organelle, which changes dynamically with the metabolic state and energy requirements of cells. Proteins that either insert into the LD phospholipid monolayer or are present in the cytoplasm, playing a crucial role in lipid homeostasis and signaling regulation, are known as LD-associated proteins.
The keywords "lipid droplets" and "metabolic diseases" were used to obtain literature on LD metabolism and pathological mechanism. After searching databases including Scopus, OVID, Web of Science, and PubMed from 2013 to 2024 using terms like "lipid droplets", "lipid droplet-associated proteins", "fatty liver disease", "diabetes", "diabetic kidney disease", "obesity", "atherosclerosis", "hyperlipidemia", "natural drug monomers" and "natural compounds", the most common natural compounds were identified in about 954 articles. Eventually, a total of 91 studies of 10 natural compounds reporting in vitro or in vivo studies were refined and summarized.
The most frequently used natural compounds include Berberine, Mangostin, Capsaicin, Caffeine, Genistein, Epigallocatechin-3-gallate, Chlorogenic acid, Betaine, Ginsenoside, Resveratrol. These natural compounds interact with LD-associated proteins and help ameliorate abnormal LDs in various metabolic diseases.
Natural compounds involved in the regulation of LDs and LD-associated proteins hold promise for treating metabolic diseases. Further research into these interactions may lead to new therapeutic applications.
脂滴（LD）是一种具有代谢活性的细胞器，其会随着细胞的代谢状态和能量需求而动态变化。那些插入脂滴磷脂单层或存在于细胞质中、在脂质稳态和信号调节中起关键作用的蛋白质，被称为脂滴相关蛋白。
使用关键词“脂滴”和“代谢性疾病”来获取有关脂滴代谢和病理机制的文献。在2013年至2024年期间，通过使用“脂滴”、“脂滴相关蛋白”、“脂肪肝疾病”、“糖尿病”、“糖尿病肾病”、“肥胖症”、“动脉粥样硬化”、“高脂血症”、“天然药物单体”和“天然化合物”等术语检索包括Scopus、OVID、科学网和PubMed在内的数据库后，在约954篇文章中确定了最常见的天然化合物。最终，对10种天然化合物的91项体外或体内研究进行了提炼和总结。
最常用的天然化合物包括黄连素、山竹黄酮、辣椒素、咖啡因、染料木黄酮、表没食子儿茶素没食子酸酯、绿原酸、甜菜碱、人参皂苷、白藜芦醇。这些天然化合物与脂滴相关蛋白相互作用，并有助于改善各种代谢性疾病中异常的脂滴。
参与调节脂滴和脂滴相关蛋白的天然化合物有望用于治疗代谢性疾病。对这些相互作用的进一步研究可能会带来新的治疗应用。
