Synthetic Biology Research Center and the K-Biofoundry, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 34141, Republic of Korea.
Department of Biosystems and Bioengineering, KRIBB School of Biotechnology, University of Science and Technology (UST), Daejeon 34113, Republic of Korea.
J Microbiol Biotechnol. 2024 Oct 28;34(10):1947-1958. doi: 10.4014/jmb.2407.07004. Epub 2024 Aug 19.
The human microbiome, consisting of microorganisms that coexist symbiotically with the body, impacts health from birth. Alterations in gut microbiota driven by factors such as diet and medication can contribute to diseases beyond the gut. Synthetic biology has paved the way for engineered microbial therapeutics, presenting promising treatments for a variety of conditions. Using genetically encoded biosensors and dynamic regulatory tools, engineered microbes can produce and deliver therapeutic agents, detect biomarkers, and manage diseases. This review organizes engineered microbial therapeutics by disease type, emphasizing innovative strategies and recent advancements. The scope of diseases includes gastrointestinal disorders, cancers, metabolic diseases, infections, and other ailments. Synthetic biology facilitates precise targeting and regulation, improving the efficacy and safety of these therapies. With promising results in animal models, engineered microbial therapeutics provide a novel alternative to traditional treatments, heralding a transformative era in diagnostics and treatment for numerous diseases.
人体微生物组由与人体共生的微生物组成，从出生起就影响着健康。饮食和药物等因素引起的肠道微生物组的改变可能会导致肠道以外的疾病。合成生物学为工程微生物疗法铺平了道路，为各种疾病提供了有前景的治疗方法。使用基因编码的生物传感器和动态调控工具，工程微生物可以产生和输送治疗剂、检测生物标志物和管理疾病。本综述按疾病类型对工程微生物疗法进行了分类，强调了创新策略和最新进展。疾病范围包括胃肠道疾病、癌症、代谢疾病、感染和其他疾病。合成生物学促进了精确的靶向和调控，提高了这些疗法的疗效和安全性。在动物模型中取得了有希望的结果，工程微生物疗法为传统治疗提供了一种新颖的替代方案，预示着诊断和治疗许多疾病的新时代的到来。
