Abdulsalam Mohammad Fathi, Shaheen Nour, Shaheen Ahmed, Alabdallat Yasmeen Jamal, Ramadan Abdelraouf, Meshref Mostafa, Mansour Fathy Mahmoud, Abed Elsayed, Fayed Abdel-Ghaffar I, Zaki Mohamed Ahmed, El-Adawy Ahmad F, Flouty Oliver, Hamed Mohamed
Department of Neurology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.
Alexandria Faculty of Medicine, Alexandria University, Alexandria, Egypt.
Front Neurol. 2024 Aug 21;15:1430231. doi: 10.3389/fneur.2024.1430231. eCollection 2024.
Cerebrovascular diseases of the brain are usually defined by transient ischemic attacks and strokes. However, they can also cause brain injuries without neurological events. Silent brain infarcts (SBI) and leukoaraiosis are symptoms of both vascular and neurological abnormalities. This study aims to investigate the association between SBI, leukoaraiosis, and middle-aged patients with ischemic stroke.
A single-center retrospective study of 50 middle-aged, ischemic stroke patients were studied from November 2022 and May 2023. The patients were divided into two groups based on the presence or absence of leukoaraiosis. History taking, physical examination, brain CT scan, and MRI were all part of the diagnostic process. Metabolic syndrome (MetS) was also assessed through various factors. The statistical analysis included descriptive statistics, logistic regression analysis, and chi-square test.
Out of the cohort comprising 50 patients, characterized by a mean age of 52.26 years (SD 5.29), 32 were male, constituting 64% of the sample. Among these patients, 26 individuals exhibited leukoaraiosis, with 17 of them (65.4%) also presenting with SBI. Moreover, within this cohort, 22 patients were diagnosed with MetS, representing 84.6% of those affected. The Multivariate logistic regression analysis showed a strong and independent association between leukoaraiosis and SBI. Individuals with leukoaraiosis were nearly five times more likely to have SBI compared to those without leukoaraiosis.
The study highlights leukoaraiosis as a significant risk factor for SBI, alongside MetS. Advanced imaging techniques have facilitated their detection, revealing a higher prevalence among stroke patients, particularly associated with age and hypertension. Further research is needed to fully understand their complex relationship and develop better management strategies for cerebrovascular diseases, ultimately improving patient outcomes.
脑部脑血管疾病通常由短暂性脑缺血发作和中风来定义。然而，它们也可在无神经事件的情况下导致脑损伤。无症状脑梗死（SBI）和脑白质疏松症是血管和神经异常的症状。本研究旨在调查SBI、脑白质疏松症与中年缺血性中风患者之间的关联。
对2022年11月至2023年5月期间的50例中年缺血性中风患者进行单中心回顾性研究。根据是否存在脑白质疏松症将患者分为两组。病史采集、体格检查、脑部CT扫描和MRI均为诊断过程的一部分。还通过各种因素评估代谢综合征（MetS）。统计分析包括描述性统计、逻辑回归分析和卡方检验。
在这50例患者组成的队列中，平均年龄为52.26岁（标准差5.29），其中32例为男性，占样本的64%。在这些患者中，26例表现出脑白质疏松症，其中17例（65.4%）也伴有SBI。此外，在该队列中，22例患者被诊断为MetS，占受影响患者的84.6%。多变量逻辑回归分析显示脑白质疏松症与SBI之间存在强烈且独立的关联。与无脑白质疏松症的个体相比，患有脑白质疏松症的个体发生SBI的可能性几乎高出五倍。
该研究强调脑白质疏松症是SBI的一个重要危险因素，与MetS一样。先进的成像技术有助于它们的检测，显示出在中风患者中的患病率较高，尤其与年龄和高血压相关。需要进一步研究以充分了解它们之间的复杂关系，并制定更好的脑血管疾病管理策略，最终改善患者预后。
