Lin Qing, Huang Wen-Qing, Ma Qi-Lin, Lu Cong-Xia, Tong Sui-Jun, Ye Jin-Hu, Lin Hui-Nuan, Gu Long, Yi Ke-Hui, Cai Liang-Liang, Tzeng Chi-Meng
Department of Neurology, The First Affiliated Hospital of Xiamen University Translational Medicine Research Center (TMRC), School of Pharmaceutical Sciences, Xiamen University, Xiamen First Clinical Medical College of Fujian Medical University, Fuzhou Key Laboratory for Cancer T-Cell Theranostics and Clinical Translation (CTCTCT), School of Pharmaceutical Sciences, Xiamen University, Xiamen, Fujian Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong INNOVA Clinics and TRANSLA Health Group, Yangzhou, Jiangsu, China.
Medicine (Baltimore). 2017 Sep;96(39):e7682. doi: 10.1097/MD.0000000000007682.
Leukoaraiosis (LA) refers to white matter hyperintensities or white matter lesions (WMLs) on magnetic resonance imaging (MRI) scans of the brain; this disease is associated with an increased risk of stroke, dementia, and cognitive decline. The aims of the study are to assess the incidence of LA and its associated risk factors in a Chinese population.A hospital-based cross-sectional study was conducted that included 4683 patients who were 40 years or older. Data collected included age, sex, hypertension, diabetes, smoking, drinking, homocysteine (HCY), and low-density lipoprotein cholesterol (LDL-C) levels in the blood in addition to brain MRI information. We examined the relationship of those putative risk factors with LA, LA occurrence, and LA progression through single-factor and multivariate analyses.Of the total subjects, 58.3% (2731/4683 cases) suffered from LA. LA was more frequent amongst elderly females, particularly in those older than 60, compared to men. The incidence of LA increased with age. Age, sex, hypertension, diabetes, smoking, and HCY levels all were risk factors for LA. Amongst those risk factors, both smoking and high HCY levels were associated with the onset process of LA. Moreover, the multivariate logistic analysis revealed that both drinking and abnormal LDL-C levels were positive regulators in the progression process of LA.This study revealed that the incidence of LA is high in hospitalized patients in China; moreover, age, sex, hypertension, diabetes mellitus, smoking, drinking, and abnormal HCY and LDL-C levels were found to be associated with overall LA risk, LA onset, or LA progression. These results provide insight into strategies for the prevention and treatment of LA.
脑白质疏松（LA）是指脑磁共振成像（MRI）扫描上的白质高信号或白质病变（WMLs）；这种疾病与中风、痴呆和认知衰退风险增加有关。本研究的目的是评估中国人群中LA的发病率及其相关危险因素。开展了一项基于医院的横断面研究，纳入了4683名40岁及以上的患者。收集的数据包括年龄、性别、高血压、糖尿病、吸烟、饮酒、血液中的同型半胱氨酸（HCY）和低密度脂蛋白胆固醇（LDL-C）水平，以及脑MRI信息。我们通过单因素和多因素分析研究了这些假定危险因素与LA、LA发生及LA进展之间的关系。在所有受试者中，58.3%（2731/4683例）患有LA。与男性相比，LA在老年女性中更为常见，尤其是60岁以上的女性。LA的发病率随年龄增长而增加。年龄、性别、高血压、糖尿病、吸烟和HCY水平均为LA的危险因素。在这些危险因素中，吸烟和高HCY水平均与LA的发病过程有关。此外，多因素逻辑分析显示，饮酒和异常LDL-C水平在LA的进展过程中均为正向调节因素。本研究表明，中国住院患者中LA的发病率较高；此外，发现年龄、性别、高血压、糖尿病、吸烟、饮酒以及异常的HCY和LDL-C水平与LA的总体风险、LA发病或LA进展有关。这些结果为LA的预防和治疗策略提供了见解。
