Sacoor Charfudin, Vitorino Pio, Nhacolo Ariel, Munguambe Khátia, Mabunda Rita, Garrine Marcelino, Jamisse Edgar, Magaço Amílcar, Xerinda Elísio, Sitoe António, Fernandes Fabíola, Carrilho Carla, Maixenchs Maria, Chirinda Percina, Nhampossa Tacilta, Nhancale Bento, Rakislova Natalia, Bramugy Justina, Nhacolo Arsénio, Ajanovic Sara, Valente Marta, Massinga Arsénia, Varo Rosauro, Menéndez Clara, Ordi Jaume, Mandomando Inácio, Bassat Quique
Manhiça Health Research Center, Municipio da Vila da Manhiça, Maputo Province, 1929, Mozambique.
Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona, Barcelona, Spain.
Gates Open Res. 2024 Sep 13;7:4. doi: 10.12688/gatesopenres.13931.1. eCollection 2023.
The Manhiça Health Research Centre (Manhiça HDSS) was established in 1996 in Manhiça, a rural district at Maputo Province in the southern part of Mozambique with approximately 49,000 inhabited households, a total population of 209.000 individuals, and an annual estimated birth cohort of about 5000 babies. Since 2016, Manhiça HDSS is implementing the Child Health and Mortality Prevention Surveillance (CHAMPS) program aiming to investigate causes of death (CoD) in stillbirths and children under the age of 5 years using an innovative post-mortem technique known as Minimally Invasive Tissue sampling (MITS), comprehensive pathogen screening using molecular methods, clinical record abstraction and verbal autopsy. Both in-hospital and community pediatric deaths are investigated using MITS. For this, community-wide socio-demographic approaches (notification of community deaths by key informants, formative research involving several segments of the community, availability of free phone lines for notification of medical emergencies and deaths, etc.) are conducted alongside to foster community awareness, involvement and adherence as well as to compute mortality estimates and collect relevant information of health and mortality determinants. The main objective of this paper is to describe the Manhiça Health and Demographic Surveillance System (HDSS) site and the CHAMPS research environment in place including the local capacities among its reference hospital, laboratories, data center and other relevant areas involved in this ambitious surveillance and research project, whose ultimate aim is to improve child survival through public health actions derived from credible estimates and understanding of the major causes of childhood mortality in Mozambique.
曼希卡健康研究中心（曼希卡卫生和人口监测系统）于1996年在莫桑比克南部马普托省的一个农村地区曼希卡成立，该地区约有49000户居民，总人口209000人，每年估计出生队列约为5000名婴儿。自2016年以来，曼希卡卫生和人口监测系统一直在实施儿童健康与死亡预防监测（CHAMPS）项目，旨在通过一种称为微创组织采样（MITS）的创新尸检技术、使用分子方法进行全面病原体筛查、临床记录摘要和口头尸检来调查死产和5岁以下儿童的死亡原因。使用MITS对医院内和社区的儿科死亡病例进行调查。为此，同时采用全社区的社会人口学方法（关键信息提供者通报社区死亡情况、涉及社区多个阶层的形成性研究、提供免费电话线用于通报医疗紧急情况和死亡情况等），以提高社区意识、参与度和依从性，并计算死亡率估计数，收集健康和死亡决定因素的相关信息。本文的主要目的是描述曼希卡卫生和人口监测系统（HDSS）站点以及现有的CHAMPS研究环境，包括其参考医院、实验室、数据中心和参与这个雄心勃勃的监测和研究项目的其他相关领域的当地能力，该项目的最终目标是通过基于可靠估计和对莫桑比克儿童死亡主要原因的理解而采取的公共卫生行动来提高儿童存活率。
