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一项关于患者耳鸣严重程度预测因素的横断面研究。

A cross-sectional study on predictors of patients' tinnitus severity.

作者信息

Li Teng-Fei, Cha Xu-Dong, Wang Tian-Yu, Liang Cai-Quan, Li Feng-Zhen, Wang Sheng-Lei, Peng Hu, Ren Wen-Wen, Deng Yue, Liu Huan-Hai

机构信息

Department of Otorhinolaryngology, Changzheng Hospital Naval Medical University (Second Military Medical University) Shanghai China.

出版信息

World J Otorhinolaryngol Head Neck Surg. 2024 Feb 3;10(3):173-179. doi: 10.1002/wjo2.151. eCollection 2024 Sep.

DOI:10.1002/wjo2.151
PMID:39233859
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11369804/
Abstract

OBJECTIVE

To identify factors that influence the severity of tinnitus via a hierarchical multiple linear regression model.

METHODS

The study was a retrospective cross-sectional analysis. The study included 331 patients experiencing tinnitus as their primary concern, who visited Shanghai Changzheng Hospital of the Navy Medical University between 2019 and 2021. Data on general health status and disease characteristics were collected from all patients. With their consent, participants underwent audiological evaluatons and completed questionnaires to analyze the characteristics of their tinnitus and the factors influencing its severity.

RESULTS

The correlation analysis showed a positive relationship between tinnitus frequency, tinnitus loudness, SAS scores, and PSQI scores with THI scores ( < 0.05) among nine examined variables (gender, handedness, employment status, age, BMI, tinnitus frequency, tinnitus loudness, SAS scores, and PSQI scores). The variables that were extracted from the multiple regression were; for the constant;  = -51.797,  = -4.484,  < 0.001, variable is significant; for the tinnitus loudness;  = 0.161,  = 2.604,  < 0.05, variable is significant; for the tinnitus frequency;  = 0.000,  = 1.269,  = 0.206, variable is not significant; for the SAS scores;  = 1.310,  = 7.685,  < 0.001, variable is significant; for the PSQI scores;  = 1.680,  = 5.433,  < 0.001, variable is significant. Therefore, the most accurate model for predicting severity in tinnitus patients is a linear combination of the constant, tinnitus loudness, SAS scores, and PSQI scores, () =   +   +  . , , , and are -51.797, 0.161, 1.310 and 1.680, respectively.

CONCLUSION

Tinnitus severity is positively associated with loudness, anxiety levels, and sleep quality. To effectively manage tinnitus in patients, it is essential to promptly identify and address these accompanying factors and related symptoms.

摘要

目的

通过分层多元线性回归模型确定影响耳鸣严重程度的因素。

方法

本研究为回顾性横断面分析。研究纳入了331例以耳鸣为主要诉求的患者,这些患者于2019年至2021年间就诊于海军军医大学附属上海长征医院。收集了所有患者的一般健康状况和疾病特征数据。在患者同意的情况下,对其进行了听力学评估,并完成了问卷以分析耳鸣的特征及影响其严重程度的因素。

结果

相关性分析显示,在九个检查变量(性别、利手、就业状况、年龄、体重指数、耳鸣频率、耳鸣响度、SAS评分和PSQI评分)中,耳鸣频率、耳鸣响度、SAS评分和PSQI评分与THI评分之间呈正相关(<0.05)。多元回归提取的变量为:常数项,=-51.797,=-4.484,<0.001,变量显著;耳鸣响度,=0.161,=2.604,<0.05,变量显著;耳鸣频率,=0.000,=1.269,=0.206,变量不显著;SAS评分,=1.310,=7.685,<0.001,变量显著;PSQI评分,=1.680,=5.433,<0.001,变量显著。因此,预测耳鸣患者严重程度的最准确模型是常数项、耳鸣响度、SAS评分和PSQI评分的线性组合,()=+++。、、、分别为-51.797、0.161、1.310和1.680。

结论

耳鸣严重程度与响度、焦虑水平和睡眠质量呈正相关。为有效管理患者的耳鸣,必须及时识别并处理这些伴随因素及相关症状。

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本文引用的文献

1
The Cross-Sectional Association Between Tinnitus and Actigraphy-Estimated Sleep in a Population-Based Cohort of Middle-Aged and Elderly Persons.基于人群的中年和老年人队列中耳鸣与活动记录仪估计睡眠的横断面关联。
Ear Hear. 2023;44(4):732-739. doi: 10.1097/AUD.0000000000001320. Epub 2022 Dec 23.
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The Relationship Between Sleep Traits and Tinnitus in UK Biobank: A Population-Based Cohort Study.英国生物银行中睡眠特征与耳鸣的关系:一项基于人群的队列研究。
Ear Hear. 2023;44(1):53-60. doi: 10.1097/AUD.0000000000001273. Epub 2022 Oct 3.
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Tinnitus: Diagnosis and Management.耳鸣:诊断与管理。
Am Fam Physician. 2021 Jun 1;103(11):663-671.
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The prevalence of tinnitus in China: a systematic review of the literature.中国耳鸣的患病率:文献系统综述。
J Laryngol Otol. 2021 Jan;135(1):3-9. doi: 10.1017/S002221512000256X. Epub 2021 Jan 22.
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Novel Risk Loci in Tinnitus and Causal Inference With Neuropsychiatric Disorders Among Adults of European Ancestry.耳鸣新风险基因座与欧洲裔成人神经精神疾病的因果推断
JAMA Otolaryngol Head Neck Surg. 2020 Nov 1;146(11):1015-1025. doi: 10.1001/jamaoto.2020.2920.
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Calculating the sample size required for developing a clinical prediction model.计算开发临床预测模型所需的样本量。
BMJ. 2020 Mar 18;368:m441. doi: 10.1136/bmj.m441.
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Sleep disturbance in PTSD and other anxiety-related disorders: an updated review of clinical features, physiological characteristics, and psychological and neurobiological mechanisms.创伤后应激障碍及其他焦虑相关障碍中的睡眠障碍:临床特征、生理特征及心理和神经生物学机制的最新综述。
Neuropsychopharmacology. 2020 Jan;45(1):55-73. doi: 10.1038/s41386-019-0486-5. Epub 2019 Aug 23.
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Tinnitus loudness and the severity of insomnia: a mediation analysis.耳鸣响度与失眠严重程度:中介分析。
Int J Audiol. 2019 Apr;58(4):208-212. doi: 10.1080/14992027.2018.1537524. Epub 2019 Jan 10.
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Sound therapy (using amplification devices and/or sound generators) for tinnitus.耳鸣的声疗法(使用放大设备和/或发声器)
Cochrane Database Syst Rev. 2018 Dec 27;12(12):CD013094. doi: 10.1002/14651858.CD013094.pub2.
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Nationwide analysis of the relationships between mental health, body mass index and tinnitus in premenopausal female adults in Korea: 2010-2012 KNHANES.韩国绝经前成年女性心理健康、体重指数与耳鸣之间关系的全国性分析:2010-2012 年韩国国民健康营养调查
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