Vaneva Irina, Kuzmanova Rumyana, Stambolieva Katerina
Department of Epilepsy, Multiprofile Hospital for Active Treatment in Neurology and Psychiatry "St. Naum", Sofia, BGR.
Department of Neurology, Medical University, Akad, Sofia, BGR.
Cureus. 2024 Aug 4;16(8):e66149. doi: 10.7759/cureus.66149. eCollection 2024 Aug.
The objective of this study is to determine and compare the relationship of the most common psychiatric comorbidities in Bulgarian patients with epilepsy with the main clinical characteristics, as well as to evaluate their impact on certain aspects of the quality of life.
Psychiatric comorbidities occur in about one-third of people with epilepsy throughout their lifetime, and their incidence is much greater in high-risk groups such as patients with treatment-resistant epilepsy.
The study group consisted of 129 participants, of whom 104 were divided into four groups according to the presence of one of the most frequently diagnosed psychiatric comorbidities in our patients with epilepsy: personality and behavioral disorder (PBD) (n=25), mild to moderate depressive disorder (n=26), anxiety disorder (n=32), and dissociative and conversion disorders (n=21). A control group was also formed with a similar number of participants with epilepsy (n=25) without psychiatric comorbidity. Some sociodemographic and clinical characteristics of epilepsy were analyzed in all patients. All patients filled out two questionnaires: the Bulgarian version of quality of life in epilepsy - 89 (QOLIE-89) and the Bulgarian version of SIDAED (assessing SIDe effects in antiepileptic drugs (AED) treatment).
The analysis revealed a negative influence of psychiatric comorbidity on the presence of epileptic seizures, unwanted drug effects, and lower scores for all aspects of the quality of life of patients with epilepsy.
The main conclusion of our study is the presence of an interaction between psychiatric comorbidity, the clinical course of the disease, and the deteriorated quality of life (QOL) in patients with epilepsy. Further attention, comprehensive care, and targeted research are needed to analyze individual psychiatric comorbidities in patients with epilepsy for early detection and treatment.
本研究的目的是确定并比较保加利亚癫痫患者中最常见的精神共病与主要临床特征之间的关系，并评估它们对生活质量某些方面的影响。
在癫痫患者的一生中，约三分之一的人会出现精神共病，而在难治性癫痫患者等高风险群体中，其发病率要高得多。
研究组由129名参与者组成，其中104人根据我们癫痫患者中最常诊断出的精神共病之一分为四组：人格与行为障碍（PBD）（n = 25）、轻度至中度抑郁症（n = 26）、焦虑症（n = 32）以及分离性和转换性障碍（n = 21）。还组建了一个对照组，其癫痫患者数量与研究组相似（n = 25），但无精神共病。分析了所有患者的一些社会人口统计学和癫痫临床特征。所有患者填写了两份问卷：保加利亚版癫痫生活质量-89（QOLIE-89）和保加利亚版SIDAED（评估抗癫痫药物（AED）治疗中的副作用）。
分析显示精神共病对癫痫发作的发生、药物不良反应以及癫痫患者生活质量各方面得分较低有负面影响。
我们研究的主要结论是癫痫患者中精神共病、疾病临床过程和生活质量（QOL）恶化之间存在相互作用。需要进一步关注、综合护理和针对性研究，以分析癫痫患者个体的精神共病，以便早期发现和治疗。
