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骨膜蒂移植治疗牙龈退缩缺损的愈合：一项在兔身上的组织学研究。

Healing of periosteal pedicle graft in the treatment of gingival recession defects: A histological study in rabbits.

作者信息

Singh Asi Kanwarjit, Mahajan Ajay, Rayast Deepa

机构信息

Department of Periodontology, Himachal Pradesh Government Dental College and Hospital, Shimla, Himachal Pradesh, India.

Department of Dental Surgery, Raipur Institute of Medical Science, Chhattisgarh, India.

出版信息

Natl J Maxillofac Surg. 2024 May-Aug;15(2):283-287. doi: 10.4103/njms.njms_187_22. Epub 2024 Jul 24.

DOI:10.4103/njms.njms_187_22
PMID:39234136
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11371282/
Abstract

PURPOSE

Various surgical techniques are described in the literature to manage gingival recession defects but the histopathologic evidence to support the current available techniques, is scarce. Recently periosteal pedicle graft (PPG) has proven to be an effective treatment option to treat gingival recession defects (GRD) with results comparable to subepithelial connective tissue graft (SCTG).

OBJECTIVE

The present histopathological study was done to evaluate the healing pattern of periosteal pedicle autogenous graft along with coronally advanced flap in the treatment of gingival recession defects.

MATERIALS AND METHODS

The present study was performed on 10 sites in 5 rabbits. Two sites were selected in each animal and gingival recession defects were surgically created and then treated using periosteal pedicle pedicle graft along with coronally advanced flap procedure. Healing pattern was assessed histopathologically at pre-defined intervals till 6 months.

RESULTS

On the 7th day of healing, dilated blood vessels with inflammatory cells were seen, while rudimentary rete-pegs appeared on 14th day. Between 3 months to 6 months, advanced histological repair with connective tissue organization with initiation of junctional epithelium, cementum and bone formation were observed.

CONCLUSION

Gingival recession defects treated with PPG had evidences of regeneration of cementum, bone and periodontal ligament fibers with new connective tissue attachment.

摘要

目的

文献中描述了多种治疗牙龈退缩缺损的手术技术，但支持当前可用技术的组织病理学证据很少。最近，骨膜蒂移植（PPG）已被证明是治疗牙龈退缩缺损（GRD）的一种有效治疗选择，其结果与上皮下结缔组织移植（SCTG）相当。

目的

进行本组织病理学研究以评估骨膜蒂自体移植联合冠向推进瓣治疗牙龈退缩缺损的愈合模式。

材料与方法

本研究在5只兔子的10个部位进行。每只动物选择两个部位，手术制造牙龈退缩缺损，然后使用骨膜蒂移植联合冠向推进瓣手术进行治疗。在预定的间隔时间直至6个月时，通过组织病理学评估愈合模式。

结果

在愈合的第7天，可见血管扩张并有炎症细胞，而在第14天出现了原始的 rete 嵴。在3个月至6个月之间，观察到具有结缔组织组织的高级组织学修复，并开始形成结合上皮、牙骨质和骨。

结论

用PPG治疗的牙龈退缩缺损有牙骨质、骨和牙周韧带纤维再生以及新的结缔组织附着的证据。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/354d/11371282/64e65cd4b3b5/NJMS-15-283-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/354d/11371282/062d8c821466/NJMS-15-283-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/354d/11371282/5fca74856a04/NJMS-15-283-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/354d/11371282/4d04573d54fd/NJMS-15-283-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/354d/11371282/4b0774b94bb6/NJMS-15-283-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/354d/11371282/459267031108/NJMS-15-283-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/354d/11371282/64e65cd4b3b5/NJMS-15-283-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/354d/11371282/062d8c821466/NJMS-15-283-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/354d/11371282/5fca74856a04/NJMS-15-283-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/354d/11371282/4d04573d54fd/NJMS-15-283-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/354d/11371282/4b0774b94bb6/NJMS-15-283-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/354d/11371282/459267031108/NJMS-15-283-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/354d/11371282/64e65cd4b3b5/NJMS-15-283-g006.jpg

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本文引用的文献

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J Indian Soc Periodontol. 2019 Sep-Oct;23(5):442-447. doi: 10.4103/jisp.jisp_676_18.
2
A Comparison of Acellular Dermal Matrix Allograft and Periosteal Pedicle Graft Covered by Coronally Advanced Flap in the Treatment of Gingival Recession: 1-Year Follow-Up Study.脱细胞真皮基质同种异体移植物与带蒂骨膜瓣覆盖的冠向推进瓣治疗牙龈退缩的比较：1年随访研究
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Multiple Gingival Recession Defects Treated with Coronally Advanced Flap and Either the VISTA Technique Enhanced with GEM 21S or Periosteal Pedicle Graft: A 9-Month Clinical Study.
采用冠向推进瓣联合VISTA技术并用GEM 21S增强或骨膜蒂移植治疗多处牙龈退缩缺损：一项为期9个月的临床研究。
Int J Periodontics Restorative Dent. 2016 Mar-Apr;36(2):231-7. doi: 10.11607/prd.2533.
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Animal models for periodontal regeneration and peri-implant responses.用于牙周再生和种植体周围反应的动物模型。
Periodontol 2000. 2015 Jun;68(1):66-82. doi: 10.1111/prd.12052.
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Periosteal pedicle graft: A novel root coverage approach.骨膜蒂移植：一种新型的牙根覆盖方法。
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