Budihastuti Uki Retno, Murti Bhisma, Prakosa Teguh, Nurwati Ida, Laqif Abdurahman, Melinawati Eriana, Hadi Cahyono, Susanto Lunardhi, Sukmawati Metanolia, Prasetya Hanung, Wijayanti Agung Sari, Ahmad Miftahul Falah
Faculty of Medicine, Universitas Sebelas Maret, Surakarta, Jawa Tengah, Indonesia.
Department of Obstetrics and Gynecology, Dr. Moewardi General Hospital, Jawa Tengah, Indonesia.
J Public Health Res. 2024 Sep 3;13(3):22799036241272394. doi: 10.1177/22799036241272394. eCollection 2024 Jul.
Approximately 50% of infertility cases are attributed to male factors. Acupuncture has long been employed as a complementary therapy to enhance male infertility treatment outcomes. This study aimed to assess the impact of electroacupuncture (EA) therapy on sperm motility and TMSC in male infertility patients.
This randomized clinical trial involved 30 male infertility patients divided into 2 groups. Consecutive sampling was utilized among men diagnosed with infertility at the Fertility Clinic Sekar, Dr. Moewardi General Hospital, Surakarta. Both groups underwent assessments of sperm motility and TMSC before and after the intervention. The first group received Coenzyme Q, while the second group received Coenzyme Q + EA.
The Qoenzyme Q + EA group exhibited no significant difference in motility levels before treatment, with an average motility of 41.40% ± 13.33 and a TMSC level of 33.59 × 10 ± 27.91. Post-treatment, motility remarkably increased by 56.40% ± 11.78, and the TMSC level rose by 78.63 × 10 ± 58.38 in the Qoenzyme Q + EA group. Conversely, the Qoenzyme Q pre-treatment group had an average motility of 48.07% ± 15.77 and a TMSC level of 30.20 × 10 ± 34.82. After Coenzyme Q treatment, a significant decrease in motility by 42.80% ± 18.03 and TMSC level by 28.22 × 10 ± 15.16 was observed.
Combining Coenzyme Q + EA had a more significant impact on sperm motility and TMSC levels than Coenzyme Q alone. These findings underscore the differential effects of Coenzyme Q + EA and Coenzyme Q on sperm motility and TMSC levels, suggesting potential therapeutic implications for male reproductive health. Future studies with larger sample sizes are warranted to validate and expand upon these results.
约50%的不孕病例归因于男性因素。长期以来,针灸一直被用作辅助疗法以提高男性不育症的治疗效果。本研究旨在评估电针(EA)疗法对男性不育症患者精子活力和睾丸间质细胞(TMSC)的影响。
这项随机临床试验纳入了30名男性不育症患者,分为2组。在苏腊卡尔塔莫瓦迪综合医院塞卡尔生育诊所被诊断为不育症的男性中采用连续抽样。两组在干预前后均接受了精子活力和TMSC评估。第一组接受辅酶Q,而第二组接受辅酶Q + EA。
辅酶Q + EA组治疗前活力水平无显著差异,平均活力为41.40%±13.33,TMSC水平为33.59×10±27.91。治疗后,辅酶Q + EA组活力显著提高至56.40%±11.78,TMSC水平升至78.63×10±58.38。相反,辅酶Q预处理组治疗前平均活力为48.07%±15.77,TMSC水平为30.20×10±34.82。辅酶Q治疗后,观察到活力显著下降42.8%±18.03,TMSC水平下降28.22×10±15.16。
与单独使用辅酶Q相比,辅酶Q + EA联合使用对精子活力和TMSC水平的影响更为显著。这些发现强调了辅酶Q + EA和辅酶Q对精子活力和TMSC水平的不同作用,提示对男性生殖健康具有潜在的治疗意义。未来需要更大样本量的研究来验证和扩展这些结果。